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Comparison of charge profiles of studied naked antibody and its corresponding ADC, including isoform number, pI range, ΔpI, and pI and % area of major species.
| Isoform number | pI range | ΔpI | pI and % area of major species | |
|---|---|---|---|---|
| Naked antibody | 2 | 8.9–9.0 | 0.1 | Peak 1: pI 8.9 : 36%, Peak 2: pI 9.0 : 64% |
| Maytansinoid-antibody | 12 | 7.5–9 | 1.5 | Peak 1: pI 8.4 : 11%, Peak 2: pI 8.5 : 15%, Peak 3: pI 8.6 : 13%, Peak 3: pI 8.7 : 11%, Peak 4: pI 8.8 : 7%, Peak 5: pI 8.9 : 4%, Peak 6: pI 9.0 : 1.7% |
