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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Lancet Oncol. 2023 May;24(5):509–522. doi: 10.1016/S1470-2045(23)00112-2

Figure 1. Skull-implantable device composed of 9 ultrasound emitters achieves large, reproducible volume of BBB opening in peri-tumoral brain.

Figure 1.

The SC9 system consists of an implantable device (A) with nine, 1 MHz ultrasound emitters that is implanted in a window in the skull during resection surgery and (B) a single-use transdermal needle that is used to connect the implantable ultrasound to a (C) pulse-generator with a touchscreen interface. (D) 3D reconstruction of post-operative computer tomography showing the implant of SC9 on a window in the skull. (E) MRI T1 with contrast sequences of two patients as representative examples of BBB opening determined by gadolinium leaking into the peri-tumoral brain after sonication, but not before sonication. From left to right, preoperative, postoperative, pre-LIPU/MB, and post-LIPU/MB MR images are provided. Brain enhancement (seen as hyper-intensity), on post-LIPU/MB that is not seen in the pre-LIPU/MB represents BBB opening with permeation of gadolinium elicited by SC9.