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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Lancet Oncol. 2023 May;24(5):509–522. doi: 10.1016/S1470-2045(23)00112-2

Figure 3. Visualization of LIPU/MB-based BBB opening for intraoperative pharmacokinetic experiment in the peri-tumoral human brain.

Figure 3.

(A) Schematic, representative intraoperative fluorescent-based microsurgical photographs illustrating how the LIPU/MB procedure was done for visualization of BBB opening using sodium fluorescein, and plasma clearance of this agent (n=10 patients). Scatter plots show correlation between PTX/ABX (n=7 patients, 81 biopsies, 41 sonicated and 40 non-sonicated) (B) and CBDCA (n=3 patients, 48 biopsies, 23 sonicated and 25 non-sonicated) (C) with fluorescein 45 minutes after LIPU/MB across biopsies of peri-tumoral brain. For A, error bars represent standard error of the mean. For B and C, Spearman correlation was computed, with two-tail p value reported.