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. 2023 Jun 9;6:624. doi: 10.1038/s42003-023-05003-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Time schedule of the experiment. b Total distance in the open field. One-way ANOVA, F(3,32) = 2.183, P = 0.1093. c Central duration in the open field. F(3,32) = 9.739, P = 0.0001. d Total distance in the elevated plus-maze. F(3,32) = 0.4678, P = 0.7068. e Time duration in the open arm. F(3,32) = 7.947, P = 0.0004. N = 9 mice in each group in (b–e). f Experimental schemes of retrograde labeling of BLA-projecting mPFC neurons. Upper panel, injection site of AAV-Retro-Cre in BLA. Lower panels, fluorescent images (left) and enlarged single neuron for cell attaching record (middle and right). Scale bar, 250 μm. g Representative traces of action potential under the fixed injection currents (150 pA). h Total spike number of BLA-projecting neurons under gradient depolarizing currents. Two-way ANOVA with respect to the group effect, F(3,710) = 50.84, P < 0.0001. n = 20 neurons from 4 mice in each group. i Representative traces of action potential under the fixed injection currents (150 pA). j Total spike number of non-BLA projecting neurons under gradient depolarizing currents. F(3,520) = 50.97, P < 0.0001. n = 13 neurons from 4 mice in each group. k Sample traces of miniature excitatory postsynaptic current (mEPSC). l Cumulative probability and comparison of means of mEPSC amplitude. One-way ANOVA, F(3,44) = 9.794, P < 0.0001. m Cumulative probability and means of mEPSC frequency. F(3,44) = 5.958, P = 0.0017. n Sample traces of miniature inhibitory postsynaptic current (mIPSC). o Cumulative probability and comparison of means of mIPSC amplitude. One-way ANOVA, F(3,44) = 6.429, P = 0.0010. p Cumulative probability and means of mIPSC frequency. F(3,44) = 6.388, P = 0.0011. n = 12 neurons from 4 animals in each group in (l, m, o, p). q Sample traces of miniature excitatory postsynaptic current (mEPSC). r Cumulative probability and comparison of means of mEPSC amplitude. One-way ANOVA, F(3,54) = 5.125, P = 0.0034. s Cumulative probability and means of mEPSC frequency. F(3,54) = 0.03437, P = 0.9914. t Sample traces of miniature inhibitory postsynaptic current (mIPSC). u Cumulative probability and comparison of means of mIPSC amplitude. One-way ANOVA, F(3,54) = 5.330, P = 0.0027. v Cumulative probability and means of mIPSC frequency. F(3,54) = 0.2435, P = 0.8656. n = 14 neurons from four animals in each group in (r, s, u, v). ns no significant difference; *P < 0.05, **P < 0.01, ****P < 0.0001. All data were presented as mean ± sem.