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. 2023 Jun 9;14:3240. doi: 10.1038/s41467-023-38704-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Pseudotime appeared to define cell pluripotency as evidenced by pluripotency markers and ectodermal markers expressed higher pseudotime corresponding to spontaneously differentiated cells. b The pseudotime projected onto the UMAP of all cells. c–e Markers representative of pseudotime progression: pluripotency (POU5F1; c), Neural Ectoderm (LIX1, d) and Epidermal Ectoderm (PTN; e). f The dynamic interaction of pseudotime with the CHCHD2 gene—hiPSC line effects are larger at smaller pseudotime values (pluripotent cells) and smaller at larger pseudotime values (spontaneously differentiated cells). The band around the lines represents the standard error. hiPSC: human induced pluripotent stem cell.