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. 2023 Jun 9;14:3395. doi: 10.1038/s41467-023-39082-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Increases in refractive index n and density at high mass fraction of monomers (acrylamide and n-hydroxymethyl acrylamide) and after photo-polymerization (arrow). ≥12 repeats per data point. ***p < 0.001 vs. A-ha monomer solution (two-sided unpaired Student’s t test). b Rigid and transparent high-n A-ha copolymer. c–k Optically cleared tissues in A-ha copolymer (representative images). c–e mouse kidney (yellow arrow). f–h mouse liver (enlarged in h; arrow, portal vein). i, j vibratome section of human pancreas in PBS vs. A-ha copolymer. The drastic increase in transmittance in A-ha is quantified in k (n = 21 and 12 independent measurements in PBS and A-ha conditions, respectively; ***p < 0.001 vs. PBS, two-sided unpaired Student’s t test). Data are presented as means ± standard deviation. Source data are provided as a Source Data file.