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. 2023 Jun 9;14:3416. doi: 10.1038/s41467-023-39140-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Product release path of qNOR from Alcaligenes xylosoxidans (AxqNOR) from the binuclear center (top) to the cytoplasmic side (bottom). AxqNOR colored in green with residues lining the proposed path in AxqNOR shown as sticks. Fe atoms and water molecules are shown as orange and red spheres, respectively. Hydrogen bonds and metal coordination bonds are shown as black and red dashed lines, respectively. This scheme is used throughout the figure. b Product release channel in qNOR from Geobacillus stearothermophilus (GsqNOR) (PDB ID: 3AYG) colored in purple, with residues lining its proposed proton channel highlighted as sticks. Zn is shown as a gray sphere. c Product release channel in qNOR from Neisseria meningitidis (NmqNOR) colored in blue, with residues lining its proposed proton channel highlighted as sticks (PDB ID: 6L3H).