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. 2023 Jun 9;14:3418. doi: 10.1038/s41467-023-39150-9

Fig. 3. Co-translationally bound Srp1 cargoes have predicted cNLSs.

Fig. 3

a Srp1 (AA 70–512) structure (orange) with peptides modeled using AlphaFold-Multimer. Only predictions i) with the ipTM+pTM score > 0.7, ii) bound to the canonical NLS-binding site in Srp1, iii) bound in the N- to C-terminus orientation as known from crystal structures of Srp1-NLS are shown (PDB: 1WA5)82. The entire data set is listed (Supplementary Data 1). b Structure-based sequence alignments derived from subpanel (a), display hallmarks of cNLSs. Regions of the target sequences are shown in the alignment indicated in parentheses (in AA). Peptides are colored by sequence conservation. *inhibitory peptide of Srp1 (PDB: 1WA5)82.