Table 2.
Evaluation of various catalyst for the synthesis of pyrazolo[3,4-b]pyridine-5-carbonitriles with UiO-66-NH2/TCT/2-Amino-py@cu.
| Entry | Catalyst | Amount of catalyst | Time (min.) | Yield (%) |
|---|---|---|---|---|
| 1 | UiO-66-NH2/TCT/2-amino-py@Cu(OAc)2 (This work) | 15 (mg) | 120 | 85 |
| 2 | UiO-66-NH245 | 15 (mg) | 180 | 22 |
| 3 | UiO-66-NH2/TCT | 15 (mg) | 180 | Trace |
| 4 | UiO-66-NH2/TCT/2-amino-py | 15 (mg) | 150 | 38 |
| 5 | Cu(OAc)2 | 15 (mol%) | 180 | 35 |
| 6 | ZrCl4 | 15 (mol%) | 180 | – |
| 7 | GTBSA55 | 15 (mg) | 120 | 74 |
| 8 | N(Et)3 | 15 (mol%) | 180 | 76 |
| 9 | [PVI-SO3H]Cl56 | 15 (mol%) | 150 | 65 |
| 10 | p-TSA | 15 (mol%) | 120 | 45 |
| 11 | NaOH | 15 (mol%) | 100 | 66 |
| 12 | Pipyridine | 15 (mol%) | 120 | 80 |
| 13 | MIL(100)(Cr)/NHEtN(CH2PO3H2)211,12 | 15 (mg) | 100 | 74 |
| 14 | KOH | 15 (mol%) | 120 | 70 |
| 15 | [Py-SO3H]Cl57 | 15 (mol%) | 120 | 63 |
| 16 | SSA58,59 | 15 (mol%) | 180 | 56 |
Significant values are in [bold].