Table 3.
Relationship between SFXN1downregulation and clinicopathological factors in non-viral cases.
| Variable | SFXN1high (n = 33) | SFXN1low (n = 11) | P-value |
|---|---|---|---|
| Age (median) | 74 (48–85) | 73 (62–82) | 0.66 |
| Sex | |||
| Male | 27 | 11 | 0.12 |
| Female | 6 | 0 | |
| Matteoni | |||
| 0 | 18 | 6 | 0.87 |
| 1, 2 | 8 | 2 | |
| 3, 4 | 7 | 3 | |
| Alcohol | 20 | 7 | 0.88 |
| Diabetes | 15 | 5 | 1.00 |
| Dyslipidemia | 9 | 5 | 0.26 |
| Obesity | |||
| BMI > 25 | 15 | 8 | 0.12 |
| BMI ≤ 25 | 17 | 3 | |
| Plt | |||
| < 10 × 104/μL | 2 | 0 | 0.40 |
| ≥ 10 × 104/μL | 31 | 11 | |
| PT | |||
| < 80% | 6 | 2 | 1.00 |
| ≥ 80% | 27 | 9 | |
| Alb | |||
| < 3.5 g/dL | 4 | 1 | 0.78 |
| ≥ 3.5 g/dL | 29 | 10 | |
| AST | |||
| > 40 IU/L | 9 | 6 | 0.10 |
| ≤ 40 IU/L | 24 | 5 | |
| ALT | |||
| > 40 IU/L | 10 | 4 | 0.71 |
| ≤ 40 IU/L | 23 | 7 | |
| T-Bil | |||
| > 1.0 mg/dL | 4 | 2 | 0.61 |
| ≤ 1.0 mg/dL | 29 | 9 | |
| ICG | |||
| > 15% | 10 | 4 | 0.71 |
| ≤ 15% | 23 | 7 | |
| α-Fetoprotein (AFP) | |||
| > 200 ng/mL | 6 | 2 | 1.00 |
| ≤ 200 ng/mL | 27 | 9 | |
| PIVKA-II | |||
| > 100 mAU/mL | 14 | 6 | 0.48 |
| ≤ 100 mAU/mL | 19 | 5 | |
| Child–Pugh grade | |||
| A | 33 | 10 | 0.56 |
| B | 0 | 1 | |
| Tumor size | |||
| > 5 cm | 14 | 6 | 0.48 |
| ≤ 5 cm | 19 | 5 | |
| Tumor number | |||
| Solitary | 30 | 7 | 0.10 |
| Multiple | 3 | 4 | |
| Differentiation | |||
| Well | 12 | 3 | 0.58 |
| Poorly/moderately | 21 | 8 | |
| Portal vein invasion | |||
| 0 | 25 | 6 | 0.18 |
| 1, 2 | 8 | 5 | |
| 3, 4 | 0 | 0 | |
| Liver status | |||
| NL | 13 | 3 | 0.47 |
| CH/LC | 20 | 8 | |
BMI body mass index, NL normal liver, CH chronic hepatitis, LC liver cirrhosis.