Table 2.
Genotype frequencies of MTR gene and HWE test of the control groupa.
| Genetic loci | Chromosome | Major allele | Minor allele | MAF | Group | Genotype frequencies | Pb | ||
|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BBc | |||||||
| rs955516 | 1:236,980,504 | T | A | 0.500 | Control | 196 (31.6%) | 314(50.6%) | 110(17.8%) | 0.414 |
| Case | 206(33.2%) | 298(48.1%) | 116(18.7%) | ||||||
| rs1266164 | 1:237,050,951 | C | T | 0.167 | Control | 427(68.9%) | 168(27.1%) | 25(4.0%) | 0.106 |
| Case | 411(66.3%) | 185(29.8%) | 24(3.9%) | ||||||
| rs3768139 | 1:237,027,668 | C | G | 0.183 | Control | 424(68.4%) | 171(27.6%) | 25(4.0%) | 0.146 |
| Case | 411(66.3%) | 185(29.8%) | 24(3.9%) | ||||||
| rs6676866 | 1:237,064,626 | G | T | 0.358 | Control | 221(35.6%) | 285(46.0%) | 114(18.4%) | 0.192 |
| Case | 190(30.6%) | 314(50.6%) | 116(18.8%) | ||||||
| rs1050993 | 1:237,062,305 | G | A | 0.189 | Control | 418(67.5%) | 177(28.5%) | 25(4.0%) | 0.257 |
| Case | 408(65.8%) | 185(29.8%) | 27(4.4%) | ||||||
| rs2229276 | 1:237,054,569 | A | G | 0.484 | Control | 175(28.2%) | 307(49.5%) | 138(22.3%) | 0.879 |
| Case | 182(29.4%) | 302(48.7%) | 136(21.9%) | ||||||
| rs4659743 | 1:237,059,387 | T | A | 0.173 | Control | 420(67.8%) | 175(28.2%) | 25(4.0%) | 0.215 |
| Case | 406(65.5%) | 183(29.5%) | 31(5.0%) | ||||||
| rs1806505 | 1:236,996,575 | C | T | 0.490 | Control | 190(30.6%) | 320(51.6%) | 110(17.8%) | 0.216 |
| Case | 219(35.3%) | 293(47.3%) | 108(17.4%) | ||||||
| rs3768142 | 1:237,028,564 | T | C | 0.294 | Control | 260(41.9%) | 269(43.4%) | 91(14.7%) | 0.119 |
| Case | 248(40.0%) | 273(44.0%) | 99(16.0%) | ||||||
| rs4659724 | 1:236,974,124 | G | A | 0.437 | Control | 192(31.0%) | 316(51.0%) | 112(18.0%) | 0.362 |
| Case | 239(38.5%) | 279(45.0%) | 102(16.5%) | ||||||
| rs6668344 | 1:237,001,326 | C | T | 0.484 | Control | 174(28.1%) | 310(50.0%) | 136(21.9%) | 0.925 |
| Case | 188(30.3%) | 305(49.2%) | 127(20.5%) | ||||||
| rs1805087 | 1:237,048,500 | A | G | 0.181 | Control | 486(78.4%) | 127(20.5%) | 7(1.1%) | 0.685 |
| Case | 408(65.8%) | 175(28.2%) | 37(6.0%) | ||||||
| rs4077829 | 1:236,987,790 | G | T | 0.440 | Control | 194(31.3%) | 316(51.0%) | 110(17.7%) | 0.339 |
| Case | 201(32.4%) | 308(49.7%) | 111(17.9%) | ||||||
| rs2275565 | 1:237,048,676 | G | T | 0.213 | Control | 475(76.6%) | 139(22.4%) | 6(1.0%) | 0.230 |
| Case | 412(66.5%) | 181(29.1%) | 27(4.4%) | ||||||
| rs3754255 | 1:237,009,857 | T | C | 0.440 | Control | 172(27.7%) | 301(48.6%) | 147(23.7%) | 0.494 |
| Case | 179(28.9%) | 286(46.1%) | 155(25.0%) | ||||||
| rs3820571 | 1:237,060,433 | T | G | 0.189 | Control | 417(67.3%) | 175(28.2%) | 28(4.5%) | 0.086 |
| Case | 416(67.1%) | 180(29.0%) | 24(3.9%) | ||||||
| rs10925252 | 1:237,022,362 | C | T | 0.490 | Control | 145(23.4%) | 298(48.1%) | 177(28.5%) | 0.368 |
| Case | 156(25.2%) | 276(44.5%) | 188(30.3%) | ||||||
| rs12060570 | 1:236,989,069 | G | C | 0.500 | Control | 193(31.1%) | 317(51.1%) | 110(17.8%) | 0.304 |
| Case | 224(36.1%) | 285(46.0%) | 111(17.9%) | ||||||
MAF minimum allele frequency.
a Data presented as number (percentage) unless otherwise indicated;
b P < 0.05 was considered to indicate a statistically significant difference;
c AA, Homezygous with minor allele; AB, Heterozygous; BB, Homezygous with major allele.