Table 3.
Genotype | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
P | OR (95% CI) | FDR_P | P | aOR (95% CI) b | FDR_Pa | |
rs955516 | ||||||
TT | 1 | 1 | 1 | 1 | 1 | 1 |
TA | 0.427 | 0.90(0.70–1.16) | 0.834 | 0.384 | 0.89(0.67–1.16) | 0.864 |
AA | 0.984 | 1.00(0.72–1.39) | 0.993 | 0.586 | 1.10(0.78–1.56) | 0.884 |
Dominant modelc | 0.544 | 0.93(0.73–1.18) | 0.703 | 0.641 | 0.94(0.73–1.22) | 0.869 |
Recessive modeld | 0.659 | 1.07(0.80–1.42) | 0.941 | 0.276 | 1.19(0.87–1.62) | 0.954 |
Additive modee | 0.871 | 0.99(0.84–1.16) | 0.990 | 0.767 | 1.03(0.86–1.22) | 0.860 |
rs1266164 | ||||||
CC | 1 | 1 | 1 | 1 | 1 | 1 |
CT | 0.289 | 1.14(0.89–1.47) | 0.834 | 0.285 | 1.16(0.89–1.51) | 0.864 |
TT | 0.993 | 0.10(0.56–1.78) | 0.993 | 0.684 | 0.88(0.47–1.65) | 0.884 |
Dominant modelc | 0.332 | 1.13(0.89–1.43) | 0.703 | 0.387 | 1.12(0.87–1.45) | 0.697 |
Recessive modeld | 0.884 | 0.96(0.54–1.70) | 0.941 | 0.583 | 0.84(0.45–1.57) | 0.954 |
Additive modee | 0.445 | 1.08(0.86–1.32) | 0.801 | 0.590 | 1.06(0.86–1.32) | 0.860 |
rs3768139 | ||||||
CC | 1 | 1 | 1 | 1 | 1 | 1 |
GC | 0.386 | 1.12(0.87–1.43) | 0.834 | 0.373 | 1.13(0.87–1.47) | 0.864 |
GG | 0.974 | 0.99(0.56–1.76) | 0.993 | 0.667 | 0.87(0.47–1.63) | 0.884 |
Dominant modelc | 0.431 | 1.10(0.87–1.40) | 0.703 | 0.487 | 1.10(0.85–1.41) | 0.797 |
Recessive modeld | 0.884 | 0.96(0.54–1.70) | 0.941 | 0.583 | 0.84(0.45–1.57) | 0.954 |
Additive modee | 0.541 | 1.06(0.87–1.30) | 0.819 | 0.692 | 1.05(0.84–1.30) | 0.860 |
rs6676866 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GT | 0.053 | 1.28(0.10–1.65) | 0.273 | 0.083 | 1.27(0.97–1.67) | 0.383 |
TT | 0.307 | 1.18(0.86–1.64) | 0.834 | 0.806 | 1.05(0.74–1.48) | 0.884 |
Dominant modelc | 0.062 | 1.25(0.99–1.59) | 0.227 | 0.153 | 1.20(0.93–1.55) | 0.424 |
Recessive modeld | 0.884 | 1.02(0.77–1.36) | 0.941 | 0.542 | 0.91(0.67–1.24) | 0.954 |
Additive modee | 0.183 | 1.11(0.95–1.31) | 0.672 | 0.532 | 1.06(0.89–1.25) | 0.860 |
rs1050993 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GA | 0.587 | 1.07(0.84–1.37) | 0.879 | 0.546 | 1.09(0.83–1.42) | 0.884 |
AA | 0.724 | 1.11(0.63–1.94) | 0.916 | 0.901 | 1.04(0.57–1.91) | 0.954 |
Dominant modelc | 0.547 | 1.08(0.85–1.36) | 0.703 | 0.556 | 1.08(0.84–1.39) | 0.834 |
Recessive modeld | 0.777 | 1.08(0.62–1.89) | 0.941 | 0.965 | 1.01(0.56–1.85) | 0.970 |
Additive modee | 0.546 | 1.06(0.87–1.30) | 0.819 | 0.611 | 1.06(0.85–1.31) | 0.860 |
rs2229276 | ||||||
AA | 1 | 1 | 1 | 1 | 1 | 1 |
AG | 0.676 | 0.95(0.73–1.23) | 0.901 | 0.976 | 1.00(0.76–1.34) | 0.976 |
GG | 0.738 | 0.95(0.69–1.30) | 0.916 | 0.628 | 1.09(0.77–1.53) | 0.884 |
Dominant modelc | 0.661 | 0.95(0.74–1.21) | 0.709 | 0.830 | 1.03(0.79–1.35) | 0.934 |
Recessive modeld | 0.891 | 0.98(0.75–1.28) | 0.941 | 0.578 | 1.08(0.82–1.44) | 0.954 |
Additive modee | 0.719 | 0.97(0.83–1.14) | 0.990 | 0.642 | 1.04(0.88–1.23) | 0.860 |
rs4659743 | ||||||
TT | 1 | 1 | 1 | 1 | 1 | 1 |
TA | 0.535 | 1.08(0.84–1.39) | 0.875 | 0.480 | 1.10(0.84–1.44) | 0.884 |
AA | 0.370 | 1.28(0.74–2.21) | 0.834 | 0.461 | 1.25(0.70–2.23) | 0.884 |
Dominant modelc | 0.399 | 1.11(0.87–1.40) | 0.703 | 0.384 | 1.12(0.87–1.44) | 0.697 |
Recessive modeld | 0.413 | 1.25(0.73–2.15) | 0.941 | 0.519 | 1.21(0.68–2.15) | 0.954 |
Additive modee | 0.320 | 1.10(0.91–1.34) | 0.799 | 0.340 | 1.11(0.90–1.37) | 0.860 |
rs1806505 | ||||||
CC | 1 | 1 | 1 | 1 | 1 | 1 |
CT | 0.072 | 0.79(0.62–1.02) | 0.288 | 0.116 | 0.80(0.61–1.06) | 0.464 |
TT | 0.339 | 0.85(0.61–1.18) | 0.834 | 0.646 | 0.92(0.65–1.31) | 0.884 |
Dominant modelc | 0.080 | 0.81(0.64–1.03) | 0.240 | 0.165 | 0.83(0.65–1.08) | 0.424 |
Recessive modeld | 0.881 | 0.98(0.73–1.31) | 0.941 | 0.751 | 1.05(0.77–1.44) | 0.970 |
Additive modee | 0.205 | 0.90(0.77–1.06) | 0.672 | 0.448 | 0.94(0.79–1.11) | 0.860 |
rs3768142 | ||||||
TT | 1 | 1 | 1 | 1 | 1 | 1 |
GT | 0.616 | 1.06(0.84–1.36) | 0.879 | 0.575 | 1.08(0.83–1.40) | 0.884 |
GG | 0.440 | 1.14(0.82–1.59) | 0.834 | 0.939 | 0.99(0.69–1.42) | 0.966 |
Dominant modelc | 0.488 | 1.08(0.86–1.36) | 0.703 | 0.676 | 1.05(0.83–1.34) | 0.869 |
Recessive modeld | 0.528 | 1.11(0.81–1.51) | 0.941 | 0.761 | 0.95(0.68–1.33) | 0.970 |
Additive modee | 0.421 | 1.07(0.91–1.25) | 0.801 | 0.889 | 1.01(0.85–1.20) | 0.889 |
rs4659724 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GA | 0.007 | 0.71(0.55–0.91) | 0.050 | 0.017 | 0.72(0.55–0.942) | 0.122 |
AA | 0.062 | 0.73(0.53–1.02) | 0.279 | 0.235 | 0.81(0.57–1.15) | 0.846 |
Dominant modelc | 0.005 | 0.72(0.57–0.90) | 0.030 | 0.022 | 0.74(0.58–0.96) | 0.132 |
Recessive modeld | 0.452 | 0.89(0.67–1.20) | 0.941 | 0.906 | 0.98(0.72–1.34) | 0.970 |
Additive modee | 0.021 | 0.83(0.71–0.97) | 0.126 | 0.106 | 0.87(0.73–1.03) | 0.636 |
rs6668344 | ||||||
CC | 1 | 1 | 1 | 1 | 1 | 1 |
CT | 0.480 | 0.91(0.70–1.18) | 0.857 | 0.789 | 0.96(0.73–1.28) | 0.884 |
TT | 0.368 | 0.86(0.63–1.19) | 0.834 | 0.810 | 0.96(0.68–1.35) | 0.884 |
Dominant modelc | 0.382 | 0.90(0.70–1.15) | 0.703 | 0.771 | 0.96(0.74–1.26) | 0.925 |
Recessive modeld | 0.532 | 0.92(0.70–1.20) | 0.941 | 0.908 | 0.98(0.74–1.32) | 0.970 |
Additive modee | 0.355 | 0.93(0.79–1.09) | 0.799 | 0.799 | 0.98(0.83–1.16) | 0.860 |
rs1805087 | ||||||
AA | 1 | 1 | 1 | 1 | 1 | 1 |
AG | < 0.001 | 1.64(1.26–2.14) | < 0.001 | 0.006 | 1.49(1.12–1.98) | 0.054 |
GG | < 0.001 | 6.30(2.78–14.27) | < 0.001 | < 0.001 | 6.85(2.94–15.96) | < 0.001 |
Dominant modelc | < 0.001 | 1.89(1.46–2.43) | < 0.001 | < 0.001 | 1.77(1.35–2.32) | < 0.001 |
Recessive modeld | < 0.001 | 5.56(2.46–12.57) | < 0.001 | < 0.001 | 6.26(2.69–14.54) | < 0.001 |
Additive modee | < 0.001 | 1.88(1.51–2.34) | < 0.001 | < 0.001 | 1.81(1.44–2.29) | < 0.001 |
rs4077829 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GT | 0.635 | 0.94(0.73–1.21) | 0.879 | 0.771 | 0.96(0.73–1.26) | 0.884 |
TT | 0.875 | 0.97(0.70–1.35) | 0.993 | 0.733 | 1.06(0.75–1.52) | 0.884 |
Dominant modelc | 0.670 | 0.95(0.75–1.21) | 0.709 | 0.918 | 0.99(0.76–1.28) | 0.964 |
Recessive modeld | 0.941 | 1.01(0.76–1.35) | 0.941 | 0.583 | 1.09(0.80–1.49) | 0.954 |
Additive modee | 0.805 | 0.98(0.83–1.15) | 0.990 | 0.812 | 1.02(0.86–1.22) | 0.860 |
rs2275565 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GT | 0.002 | 1.50(1.16–1.94) | 0.018 | 0.003 | 1.52(1.15–1.20) | 0.036 |
TT | < 0.001 | 5.19(2.12–12.69) | < 0.001 | 0.001 | 4.93(1.93–12.58) | 0.018 |
Dominant modelc | < 0.001 | 1.65(1.29–2.12) | < 0.001 | < 0.001 | 1.66(1.27–2.17) | < 0.001 |
Recessive modeld | 0.001 | 4.66(1.91–11.37) | < 0.001 | 0.002 | 4.41(1.73–11.22) | 0.018 |
Additive modee | < 0.001 | 1.68(1.34–2.10) | < 0.001 | < 0.001 | 1.68(1.32–2.13) | < 0.001 |
rs3754255 | ||||||
TT | 1 | 1 | 1 | 1 | 1 | 1 |
TC | 0.500 | 0.91(0.70–1.19) | 0.857 | 0.302 | 0.86(0.65–1.14) | 0.864 |
CC | 0.934 | 1.01(0.75–1.38) | 0.993 | 0.565 | 0.91(0.65–1.27) | 0.884 |
Dominant modelc | 0.659 | 0.95 (0.74–1.21) | 0.709 | 0.327 | 0.88(0.67–1.14) | 0.697 |
Recessive modeld | 0.597 | 1.07(0.84–1.39) | 0.941 | 0.970 | 0.10(0.75–1.32) | 0.970 |
Additive modee | 0.969 | 1.00(0.86–1.17) | 1.000 | 0.523 | 0.95(0.80–1.12) | 0.860 |
rs3820571 | ||||||
TT | 1 | 1 | 1 | 1 | 1 | 1 |
TG | 0.809 | 1.03(0.80–1.32) | 0.971 | 0.726 | 1.05(0.80–1.37) | 0.884 |
GG | 0.597 | 0.86(0.49–1.51) | 0.879 | 0.357 | 0.75(0.41–1.38) | 0.864 |
Dominant modelc | 0.952 | 1.01(0.80–1.28) | 0.952 | 0.964 | 1.01(0.78–1.30) | 0.964 |
Recessive modeld | 0.571 | 0.85(0.49–1.49) | 0.941 | 0.329 | 0.74(0.40–1.36) | 0.954 |
Additive modee | 0.880 | 0.99(0.81–1.20) | 0.990 | 0.757 | 0.97(0.78–1.20) | 0.860 |
rs10925252 | ||||||
CC | 1 | 1 | 1 | 1 | 1 | 1 |
CT | 0.293 | 0.86(0.65–1.14) | 0.834 | 0.085 | 0.77(0.57–1.04) | 0.383 |
TT | 0.934 | 0.99(0.73–1.34) | 0.993 | 0.357 | 0.86(0.62–1.19) | 0.864 |
Dominant modelc | 0.466 | 0.91(0.70–1.18) | 0.703 | 0.117 | 0.80 (0.61–1.06) | 0.424 |
Recessive modeld | 0.493 | 1.09(0.85–1.39) | 0.941 | 0.909 | 1.02(0.78–1.33) | 0.970 |
Additive modee | 1.000 | 1.00(0.86–1.16) | 1.000 | 0.390 | 0.93(0.79–1.10) | 0.860 |
rs12060570 | ||||||
GG | 1 | 1 | 1 | 1 | 1 | 1 |
GC | 0.046 | 0.78(0.60–0.99) | 0.273 | 0.061 | 0.77(0.59–1.01) | 0.366 |
CC | 0.401 | 0.87(0.63–1.21) | 0.834 | 0.775 | 0.95(0.67–1.35) | 0.884 |
Dominant modelc | 0.063 | 0.80 (0.63–1.01) | 0.227 | 0.121 | 0.82(0.63–1.06) | 0.424 |
Recessive modeld | 0.941 | 1.01(0.76–1.35) | 0.941 | 0.508 | 1.11(0.81–1.51) | 0.954 |
Additive modee | 0.224 | 0.91(0.77–1.06) | 0.672 | 0.499 | 0.94(0.79–1.12) | 0.860 |
aOR = adjusted odds ratio; CI = confidence interval.
a P < 0.05 was considered to indicate a statistically significant difference;
b Adjusted for residence, BMI before pregnancy, history of gestational diabetes mellitus, history of gestational hypertension, history of consanguineous marriage, family history of congenital malformations, cold before pregnancy, smoking before pregnancy, alcohol drinking before pregnancy, and folate supplement before or during pregnancy.
c Dominant model means homozygous variant + heterozygous variant versus homozygous wild-type.
d Recessive model means homozygous variant versus heterozygous variant + homozygous wild-type.
e Additive model means homozygous variant versus heterozygous variant versus homozygous wild-type.
Significant values are in [bold].