Table 4.
Haplotype frequencies of MTR genetic polymorphisms.
| Haplotypes | Case (%) | Control (%) | aOR (95%CI) b | P | FDR_Pa |
|---|---|---|---|---|---|
| rs4659724-rs95516-rs4077829 | |||||
| GTG | 700.9(56.7%) | 689.8(55.8%) | 1 | ||
| AAT | 477.9(38.7%) | 521.8(42.2%) | 0.90 (0.77–1.06) | 0.072 | 0.144 |
| GAT | 45.1(3.7%) | 8.1(0.7%) | 5.48(2.58–11.66) | < 0.001 | < 0.001 |
| rs12060570-rs1806505-rs6668344-rs3754255 | |||||
| GCCC | 588.9(47.6%) | 591.9(47.7%) | 1 | ||
| CTTT | 501.9(40.6%) | 533.9(43.1%) | 0.95(0.80–1.12) | 0.217 | 0.362 |
| GCCT | 85.7(6.9%) | 60.0(4.8%) | 1.44(1.01–2.03) | 0.027 | 0.068 |
| GCTT | 51.4(4.2%) | 48.1(3.9%) | 1.07(0.71–1.62) | 0.721 | 0.801 |
| rs3768139-rs3768142 | |||||
| CT | 768.3(62.0%) | 782.4(63.1%) | 1 | ||
| CG | 238.7(19.3%) | 236.6(19.1%) | 1.03(0.84–1.26) | 0.916 | 0.916 |
| GG | 232.3(18.7%) | 214.4(17.3%) | 1.10(0.89–1.36) | 0.349 | 0.499 |
| rs2275565-rs1266164-rs2229276-rs4659743-rs3820571-rs1050993 | |||||
| GCGTTG | 554.9(45.0%) | 579.3(46.9%) | 1 | ||
| GCATTG | 212.1(17.2%) | 282.7(22.9%) | 0.78(0.63–0.97) | < 0.001 | < 0.001 |
| GTAAGA | 228.0(18.5%) | 213.0(17.2%) | 1.12(0.90–1.39) | 0.420 | 0.525 |
| TCATTG | 213.9(17.3%) | 139.3(11.3%) | 1.60(1.26–2.04) | < 0.001 | < 0.001 |
aOR ,adjusted odds ratio; CI, confidence interval.
a P < 0.05 was considered to indicate a statistically significant difference;
b The aOR values and 95% CIs were calculated using binary logistic regression and adjusted for residence, BMI before pregnancy, history of gestational diabetes mellitus, history of gestational hypertension, history of consanguineous marriage, family history of congenital malformations, cold before pregnancy, smoking before pregnancy, alcohol drinking before pregnancy, and folate supplement before or during pregnancy.
Significant values are in [bold].