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. 2023 Jun 5;18:2989–3006. doi: 10.2147/IJN.S407116

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© 2023 Chao et al.

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Interaction between circSH3PXD2A and miR-375-3p. (A) Venn diagram showing circSH3PXD2A-related miRNAs screened by the intersection of miRanda, RNAhybrid, TargetScan, and circRNA sequence data. (B) Expression levels of candidate circSH3PXD2A-related miRNAs (miR-375-3p and miR-370-3p) in H446 and SHP77 cells. (C) Volcano plot for differentially expressed miRNAs in H446 and SHP77 cells. (D) The expression level of miR-375-3p was detected in SCLC cells transfected with circSH3PXD2A overexpression lentivirus or circSH3PXD2A siRNA. (E and F) Biotin-coupled miR-375-3p mimic was used to pull down circSH3PXD2A, and the expression level of circSH3PXD2A was analyzed through qRT‒PCR and agarose gel electrophoresis. (G) The sequences of circSH3PXD2A wild type and mutant type, and the detection of luciferase activities of circSH3PXD2A in H446 cells cotransfected with miR-375-3p mimic or negative controls. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.

Abbreviation: ns, no significance.