Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 5;18:2989–3006. doi: 10.2147/IJN.S407116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Chao et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

CircSH3PXD2A acts as a sponge for miR-375-3p to suppress chemoresistance in SCLC. (A) The transfection efficiency of miR-375-3p mimic (left) or inhibitor (right) was determined by qRT‒PCR. (B) After transfected with miR-375-3p mimic (left) or inhibitor (left), the chemoresistance of SCLC cells to the chemotherapeutic drugs DDP, ADM and VP-16 was detected by chemoresistance assay. (C) The effect of miR-375-3p on the apoptosis of SCLC cells was analyzed by flow cytometry. (D) The proliferation rate of SCLC cells was detected by CCK-8 assay. (E) Transwell assays were applied to analyze the influence of miR-375-3p on the migration and invasion of SCLC cells. Scale bar, 100 μm. (F) Comparison of the miR-375-3p levels in SHP77 cells transfected with vector, circ-oe, and circ-oe+miR-375-3p mimic. (G and H) The cell proliferation ability (G) and chemoresistance (H) of SCLC cells were detected after cotransfection of circSH3PXD2A and miR-375-3p mimic. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.