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. 2023 Jun 9;14:3390. doi: 10.1038/s41467-023-38859-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Overview of workflow for structural analysis. B Global pairwise structural similarity (Pearson correlation R) across metabolic proteins based on calculated structural properties from the E. coli GEM-PRO. C Global structural similarity (Pearson correlation R) of DHFR, the intended target of CD15-3, to other genes. D Overview of folate pathway and protein structures extracted from PDB. E Results for whole structure similarity analysis utilizing FATCAT. Low p-values reported by FATCAT indicate more similar structures. F Results for active site analysis using isomif for comparison. Protein structure identifiers are taken from PDB. Color scale shows FATCAT p-values from 0.0 in black to 1.0 in white.