Table 4.

Candidates for core gene status based on trans-effects on protein levels

Protein name	Gene encoding protein	Transcription site		trans-score			cis-score
		Chr	Start position (Mb)	Effective number of pQTLs	Log odds ratio	p value	Log odds ratio	p value
Eukaryotic translation initiation factor 4 gamma 3	EIF4G3	1	20.81	13.0	−0.12	$1\times {10}^{-10}$	–	–
CD5 antigen-like	CD5L	1	157.83	15.7	0.10	$6\times {10}^{-8}$	−0.01	0.6
CD48 antigen	CD48	1	160.68	10.0	0.10	$7\times {10}^{-8}$	−0.03	0.2
Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	1	161.62	10.5	0.10	$5\times {10}^{-7}$	0.01	0.7
Glucagon	GCG	2	162.14	8.0	0.09	$6\times {10}^{-7}$	–	–
Monokine induced by interferon-gamma (CXCL9)	CXCL9	4	76.00	11.4	0.10	$2\times {10}^{-7}$	−0.06	0.001
C-C motif chemokine 19	CCL19	9	34.69	9.4	0.16	$2\times {10}^{-16}$	0.04	0.05
Cytotoxic and regulatory T cell molecule	CRTAM	11	122.84	9.8	0.15	$1\times {10}^{-15}$	−0.02	0.3
Lymphocyte activation gene 3 protein	LAG3	12	6.77	16.4	0.09	$8\times {10}^{-7}$	–	–
C-C motif chemokine 15	CCL15	17	36.00	19.9	−0.11	$2\times {10}^{-8}$	−0.02	0.2
Intercellular adhesion molecule 2	ICAM2	17	64.00	18.0	0.10	$5\times {10}^{-7}$	–	–
Protein lin-7 homolog B	LIN7B	19	49.11	15.9	−0.12	$2\times {10}^{-10}$	–	–
Natural cytotoxicity triggering receptor 1	NCR1	19	54.91	7.7	0.12	$1\times {10}^{-10}$	0.05	0.01
BPI fold-containing family A member 2	BPIFA2	20	33.16	6.0	0.10	$2\times {10}^{-7}$	0.04	0.02

Genes included in this table are those with trans-scores that are associated with T1D at $\mathrm{p}<{10}^{-6}$, with effective number of pQTLs > 5.