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. 2022 Nov 9;122(11):2041–2052. doi: 10.1016/j.bpj.2022.11.011

Figure 4.

Figure 4

Packing and interactions of neighboring protomers in predicted CAV1 complexes are similar to their counterparts in the cryo-EM-based structure. (A–L) Comparison of en face and side views of secondary structure model of cryo-EM-based CAV1 11-mer complex with structures of CAV1 10-, 11- and 12-mer predicted by AF2.2. Dimensions of complexes are labeled in (B), (E), (H), and (K). Cut-through views of each model are shown in (C), (F), (I), and (L). Residues 1–48 and 178 were hidden from the AF2.2-predicted structures to make them more comparable to the cryo-EM structure. Two neighboring protomers from each model are highlighted in gradually warming colors. All structures are shown to scale. (M and O) Overlay of two neighboring dimers extracted from each of the models shown in (A)–(L). Protomers from the cryo-EM structure are shown in beige or white. (N and P) Close up of boxed regions from (M) and (O) showing zoomed views of the key residues in the pin motif (N) and in surrounding P132 (P).