Table 1.
Overall patient features according to model suggestion in the test set
| Characteristic | No Suggestion (n = 4,223) | Fast Infusion (n = 735) | Slow Infusion (n = 277) |
|---|---|---|---|
| Age | 62 (50–72) | 79 (69–86) | 36 (28–43) |
| Female sex | 1,771 (42%) | 355 (48%) | 136 (49%) |
| APACHE II score | 11 (8–15) | 17 (13–23) | 7 (5–10) |
| SOFA score | 4.0 (2.0–6.0) | 5.0 (3.0–8.0) | 4.0 (2.0–6.0) |
| Mean arterial pressure, mm Hg | 74 (63–87) | 70 (60–84) | 73 (64–84) |
| Heart rate, beats per min | 92 (77–109) | 96 (81–112) | 97 (81–111) |
| Vasopressor use | 1,627 (39%) | 190 (26%) | 164 (59%) |
| Acute kidney injury at enrollment | 1,222 (29%) | 398 (54%) | 57 (21%) |
| Creatinine, mg/dl | 0.95 (0.71–1.28) | 1.24 (0.90–1.94) | 0.80 (0.60–1.07) |
| Admission type | |||
| Unplanned, not sepsis | 1,249 (30%) | 264 (36%) | 52 (19%) |
| Planned | 2,480 (59%) | 23 (3.1%) | 225 (81%) |
| Unplanned, sepsis | 494 (12%) | 448 (61%) | 0 |
| Mechanical ventilation | 2,276 (54%) | 435 (59%) | 48 (17%) |
| Noninvasive ventilation | 31 (0.7%) | 0 | 9 (3.2%) |
| Intensive care unit length of stay | 3 (2–6) | 5 (2–11) | 3 (2–4) |
| Hospital length of stay | 8 (5–16) | 10 (5–21) | 8 (6–15) |
| Need for kidney replacement therapy | 283 (6.7%) | 86 (12%) | 10 (3.6%) |
| Hospital mortality | 771 (18%) | 339 (46%) | 22 (7.9%) |
| 90-d mortality | 897 (21%) | 388 (53%) | 32 (12%) |
Definition of abbreviations: APACHE = Acute Physiology and Chronic Health Evaluation; SOFA = Sequential Organ Failure Assessment.
Values presented as median (interquartile range) where applicable.