Table 3.

Correlation Analysis Between Pathological Characteristics and Laboratory Indicators of HCC with Metabolic Risk Factors

	Swelling and Ballooning of Tumor Cells		Steatosis in Surrounding Liver Tissue		Inflammation in Surrounding Liver Tissue		Fibrosis in Surrounding liver Tissue		Cirrhosis		CK19		HepPar1		GPC3		HSP70
	r value	P value	r value	p value	r value	p value	r value	p value	r value	p value	r value	p value	r value	p value	r value	p value	r value	p value
Differentiation of HCC	0.058	0.754	−0.202	0.275	−0.072	0.799	0.441	0.100	−0.084	0.647	0.770	0.000	−0.375	0.041	−0.281	0.126	0.130	0.632
Cirrhosis	0.499	0.004	0.254	0.167	0.000	1.000	0.820	0.000	–	–	−0.112	0.564	−0.025	0.894	0.464	0.009	0.491	0.053
Obesity	−0.033	0.860	0.215	0.245	0.000	1.000	0.080	0.776	0.110	0.548	0.012	0.950	−0.209	0.267	0.013	0.946	0.029	0.915
T2DM	−0.034	0.853	0.238	0.197	0.062	0.826	−0.020	0.944	0.130	0.479	−0.125	0.518	−0.063	0.741	−0.098	0.599	−0.169	0.531
Hypertension	0.173	0.345	0.096	0.609	−0.211	0.451	−0.100	0.722	−0.049	0.791	−0.510	0.005	0.357	0.053	0.262	0.155	0.196	0.467
Elevated TG level	−0.323	0.071	−0.336	0.065	−0.311	0.260	−0.197	0.481	−0.420	0.017	−0.045	0.815	0.192	0.310	−0.008	0.966	−0.166	0.539
Decreased HDL-C level	0.208	0.254	0.131	0.481	−0.585	0.022	0.302	0.275	0.037	0.842	−0.100	0.607	0.357	0.053	−0.072	0.701	0.231	0.389
ALT	−0.051	0.761	−0.072	0.721	0.040	0.887	−0.161	0.567	0.021	0.911	−0.355	0.059	0.034	0.858	0.260	0.158	0.499	0.049
AST	0.015	0.934	−0.242	0.223	0.253	0.363	−0.018	0.949	0.024	0.896	−0.002	0.992	−0.163	0.390	0.063	0.738	0.123	0.650
AKP	−0.227	0.219	−0.555	0.003	0.397	0.143	−0.225	0.421	−0.336	0.064	0.192	0.328	−0.140	0.468	0.019	0.920	0.299	0.279
GGT	−0.097	0.603	−0.386	0.047	0.115	0.683	0.124	0.659	−0.117	0.531	0.093	0.637	−0.022	0.911	−0.053	0.781	0.409	0.130
TBil	−0.019	0.920	0.294	0.137	−0.012	0.968	0.184	0.511	0.389	0.028	−0.074	0.703	−0.066	0.728	0.267	0.147	0.517	0.040
DBiL	0.169	0.356	0.164	0.413	−0.069	0.807	0.403	0.137	0.396	0.025	−0.010	0.958	−0.076	0.690	0.252	0.171	0.614	0.011
TCHO	−0.442	0.016	−0.041	0.864	0.311	0.260	−0.741	0.002	−0.456	0.013	0.014	0.946	−0.024	0.907	−0.301	0.119	−0.520	0.047
LDL-C	−0.493	0.007	0.057	0.786	0.167	0.552	−0.726	0.002	−0.497	0.006	0.078	0.705	0.002	0.992	−0.317	0.100	−0.496	0.060
APO-A1	−0.381	0.041	0.094	0.655	0.115	0.683	−0.647	0.009	0.050	0.798	−0.114	0.581	−0.104	0.606	0.067	0.736	−0.233	0.404
APO-B	−0.428	0.020	0.048	0.819	0.167	0.552	−0.586	0.022	−0.510	0.005	0.132	0.520	−0.032	0.876	−0.363	0.057	−0.542	0.037
LP(a)	−0.073	0.723	−0.551	0.008	0.570	0.033	−0.177	0.544	−0.252	0.214	0.335	0.102	−0.397	0.055	−0.416	0.039	−0.294	0.307
GLU	0.048	0.794	0.097	0.629	0.213	0.446	−0.062	0.826	−0.031	0.866	−0.027	0.888	0.115	0.547	−0.389	0.031	−0.253	0.344
TP	−0.534	0.002	−0.128	0.524	0.371	0.173	−0.613	0.015	−0.403	0.022	−0.073	0.707	0.087	0.647	−0.050	0.789	−0.310	0.243
AFP	−0.273	0.130	−0.016	0.938	0.224	0.422	0.153	0.585	0.114	0.535	−0.033	0.865	−0.026	0.891	0.446	0.012	0.488	0.055
WBC	−0.471	0.007	−0.281	0.156	−0.265	0.341	−0.672	0.006	−0.596	0.000	0.313	0.099	−0.171	0.368	−0.231	0.212	0.076	0.780
RBC	−0.607	0.000	0.040	0.845	−0.207	0.459	−0.464	0.082	−0.296	0.100	0.134	0.487	0.071	0.708	0.021	0.910	−0.052	0.847
Hb	−0.665	0.000	−0.044	0.828	−0.012	0.968	−0.276	0.320	−0.276	0.127	0.022	0.908	0.045	0.815	0.075	0.690	0.059	0.828
PLT	−0.337	0.034	−0.061	0.764	−0.115	0.683	−0.613	0.015	−0.741	0.000	0.057	0.770	0.092	0.630	−0.382	0.034	−0.074	0.784

Abbreviations: CK19, Cytokeratin 19; GPC-3, glypican-3; HSP70, heat shock protein 70; HCC, hepatocellular carcinoma; T2DM, type 2 diabetes mellitus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AKP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; TBiL, total bilirubin; DBiL, direct bilirubin; TCHO, total cholesterol; LDL-C, low-density liptein cholesterol; APO-A1, apolipoprotein A1; ApoB, apolipoprotein B; LPa, lipoprotein(a); GLU, Glucose; TP, Total Protein; AFP, Alpha-FetoProtein; WBC, White blood cell; RBC, Red blood cell; Hb, Hemoglobin; PLT, platelet.