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. 2023 Feb 13;68(6):638–650. doi: 10.1165/rcmb.2022-0264OC

Figure 6.

Figure 6.

Inhibition of ATP12A by potassium-competitive proton pump blocker VON reduced BLEO-induced pulmonary fibrosis in mice expressing ATP12A. (A) Bright-field microscope images of mouse lung tissue stained with Masson’s trichrome show collagen deposition (blue) in the lung; the left panel shows collagen deposition throughout the lung (scale bars, 100 μm), and the right panel shows collagen deposition in the peribronchial area (scale bars, 10 μm). (B) The chart shows the fibrosis index in mouse lungs. Data are expressed as mean ± SD, with n ⩾ 5 animals per group. (C) The chart shows parabronchial collagen thickness (in micrometers) in mouse lungs. Data are expressed as mean ± SD. n ⩾ 5 animals per group. ***P < 0.001 compared to CTL; ###P < 0.001 compared to B+ATP12A+VON.