Table 7.
Significant cis-Protein Quantitative Trait Locus Results with False Discovery Rate Lower than 0.05 Regulating Chronic Obstructive Pulmonary Disease-Associated Proteins (False Discovery Rate < 0.05)
| SNP* | Ref | Alt | SNP Location | GWAS SNP Region (LD r2) | Top Protein Region | Gene Name (UniProt) | Gene Location | QTL |
||
|---|---|---|---|---|---|---|---|---|---|---|
| P Value† | FDR‡ | β (SE)† | ||||||||
| rs111516029 | C | T | chr11:75578285 | NA | ARRB1 (P49407) | ARRB1 (P49407) | chr11:75260122-75351705 | 2.63 × 10−5 | 2.31 × 10−2 | 0.785 (0.177) |
| rs4808102 | A | G | chr19:17909876 | NA | COLGALT1 (Q8NBJ5) | COLGALT1 (Q8NBJ5) | chr19:17555649-17583162 | 4.75 × 10−5 | 4.01 × 10−2 | 0.819 (0.192) |
*
For genomic regions around each COPD-associated proteins and each target gene, only one significant top pQTL association is presented.
†
Positive β-coefficients mean higher expression level for the alternative allele.
‡
FDR were adjusted with COPD risk SNPs.