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Mapping pathogenic variants to known motifs and binding pockets. (A+B) OPSD variants that lie within the retinal binding pocket and conserved GPCR motifs. (C+D) GTR1 variants within proximity of a PEG molecule (P33), matching previously identified inhibitor positions (71), and the chloride binding side, along with conserved sugar transporter motifs. To see this figure in color, go online.
