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. Author manuscript; available in PMC: 2023 Jun 10.
Published in final edited form as: Nature. 2018 Jul 18;560(7716):55–60. doi: 10.1038/s41586-018-0342-5

Extended Data Figure 8: ALL cell invasion along laminin matrices is regulated by PI3K signaling and α6 integrin.

Extended Data Figure 8:

a, 1° ALL and Nalm-6 in vitro invasion toward hCSF along collagen, collagen + laminin, or collagen + fibronectin matrices (mean ± s.e.m., ANOVA with Tukey, n = 3 biologically independent experiments, 1° ALL: P = 0.8937 (collagen vs. 0.001mg/ml laminin), P = 0.0020 (collagen vs. 0.005 mg/ml laminin), P < 0.0001 (collagen vs. 0.01 mg/ml laminin), P = 0.0604 (0.01 mg/ml laminin vs. fibronectin), Nalm-6: P = 0.0012 (collagen vs. 0.01 mg/ml laminin), P = 0.0150 (0.01 mg/ml laminin vs. fibronectin). b, Comparative in vitro invasion of low α6 integrin-expressing ALL cells vs. high α6 integrin-expressing ALL cells towards hCSF along laminin matrices and effects of PI3Kδ inhibition or α6 integrin blockade (mean ± s.e.m., ANOVA with Tukey, n = 3 biologically independent experiments, REH: P > 0.9999 (collagen vs. laminin), P = 0.6967 (collagen+laminin vs. collagen+laminin+GS649443), P > 0.9999 (collagen+laminin vs. collagen+laminin+anti-α6), 1° ALL: P = 0.9758 (collagen vs. laminin), P = 0.9974 (collagen+laminin vs. collagen+laminin+GS649443), P = 0.9993 (collagen+laminin vs. collagen+laminin+anti-α6), RCH: P = 0.2446 (collagen vs. laminin), P = 0.0079 (collagen+laminin vs. collagen+laminin+GS649443), P = 0.2549 (collagen+laminin vs. collagen+laminin+anti-α6), SUP-B15: P = 0.0122 (collagen vs. laminin), P = 0.0080 (collagen+laminin vs. collagen+laminin+GS649443), P = 0.0112 (collagen+laminin vs. collagen+laminin+anti-α6). *P < 0.05, ** < 0.01, *** <0.001.