. Author manuscript; available in PMC: 2023 Jun 10.

Published in final edited form as: Clin Genitourin Cancer. 2022 Jun 5;20(5):e440–e452. doi: 10.1016/j.clgc.2022.06.001

Table 2.

Lymph Node Metastatic Disease Model.

	Metastatic Sites	ORR	OR	PFS	HR	OS	HR
1st line ICI	Non LN - confined disease	22 (18–26)	reference	3 (3–4)	reference	9 (7–12)	reference
	LN - confined disease	45 (37–54)	2.97 (1.92–4.59) ^a	11 (7–16)	0.53 (0.41–0.69) ^a	22 (14-NR)	0.49 (0.37–0.65) ^a
2nd line ICI or greater
	Non LN - confined disease	19 (15–23)	reference	4 (3–4)	reference	8 (6–9)	reference
	LN - confined disease	38 (28–49)	2.79 (1.50–5.16) ^a b	13 (6–21)	0.47 (0.34–0.65) ^a	18 (11-NR)	0.54 (0.38–0.77) ^a c

P < .05.

adjusted for cystectomy and albumin at ICI initiation.

adjusted for albumin.