. Author manuscript; available in PMC: 2023 Jun 10.

Published in final edited form as: Clin Genitourin Cancer. 2022 Jun 5;20(5):e440–e452. doi: 10.1016/j.clgc.2022.06.001

Table 4.

Liver, Bone and Lung Metastasic Disease Model.

	Metastatic Sites	ORR	aOR	PFS	aHR	OS	aHR
1st line ICI
	No liver-bone-lung	37 (31–43)	Reference	7 (5–11)	Reference	17 (12–22)	Reference
	Bone - only	20 (12–33)	0.48 (0.23–1.01) ^b	3 (2–5)	1.42 (0.93–2.16) ^c	7 (3–13)	1.55 (0.96–2.51) ^d
	Liver - only	13 (5–29)	0.21 (0.06–0.72) ^a b	2 (1–3)	2.43 (1.55–3.83) ^a c	5 (3–14)	2.46 (1.54–3.94) ^a d
	Lung-only	26 (18–35)	0.69 (0.40–1.21) ^b	4 (3–6)	1.32 (0.96–1.83) ^c	18 (11–23)	1.25 (0.87–1.79) ^d
	Liver & bone	6 (1–32)	0.14 (0.02–1.04) ^b	1 (1–4)	2.09 (1.08–4.05) ^a c	2 (1–5)	2.81 (1.46–5.37) ^a d
	Lung & bone	24 (10–46)	0.31 (0.09–1.11) ^b	4 (1–12)	1.39 (0.71–2.74) ^c	11 (3-NR)	1.59 (0.80–3.14) ^d
	Lung & liver	19 (6–45)	0.33 (0.07–1.65) ^b	2 (2–3)	2.52 (1.40–4.55) ^a c	4 (2–7)	3.74 (2.11–6.62) ^a d
	Lung, liver & bone	0	-	2 (0.2–2)	3.92 (1.77–8.70) ^a c	2 (0.2–13)	4.41 (2.19–8.88) ^a d
2nd line ICI or greater
	No liver-bone	32 (25–41)	Reference	7 (5–10)	Reference	14 (11–19)	Reference
	Bone - only	14 (7–25)	0.25 (0.09–0.72) ^a e	4 (3–7)	1.75 (1.17–2.63) ^a f	8 (5–10)	1.87 (1.24–2.82) ^a g
	Liver - only	24 (13–39)	0.49 (0.20–1.23) ^e	3 (2–4)	2.20 (1.34–3.59) ^a f	9 (4–14)	1.61 (0.93–2.80) ^g
	Lung-only	22 (15–32)	0.67 (0.33–1.36) ^e	4 (3–6)	1.58 (1.10–2.28) ^a f	8 (6–12)	1.33 (0.90–1.97) ^g
	Liver & Bone	9 (2–30)	0.28 (0.05–1.52) ^e	2 (1–3)	2.91 (1.30–6.52) ^a f	2 (2–5)	2.80 (1.21–6.44) ^a g
	Lung & bone	8 (3–23)	0.25 (0.07–0.87) ^a e	3 (2–5)	2.49 (1.72–3.61) ^a f	6 (4–9)	1.96 (1.31–2.95) ^a g
	Lung & liver	26 (12–47)	1.13 (0.34–3.83) ^e	3 (2–3)	2.34 (1.27–4.33) ^a f	4 (3–9)	2.14 (1.14–4.02) ^a g
	Lung, liver & bone	15 (4–45)	0.60 (0.13–2.80) ^e	2 (1–3)	2.64 (1.24–5.60) ^a f	3 (1–9)	2.78 (1.26–6.15) ^a g

P < .05.

adjusted for cystectomy, site of primary (upper vs. lower), albumin at ICI initiation and NLR at ICI initiation.

adjusted for cystectomy, site of primary (upper vs. lower), and albumin at ICI initiation.

adjusted for cystectomy, site of primary (upper vs. lower), ECOG at ICI initiation, albumin, hemoglobin and NLR at ICI initiation.

adjusted for cystectomy, site of primary (upper vs. lower), albumin, hemoglobin and NLR at ICI initiation.

adjusted for cystectomy, albumin, hemoglobin and NLR at ICI initiation.

adjusted for cystectomy, ECOG at ICI initiation, albumin, hemoglobin and NLR at ICI initiation.