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Enhanced variant peptides derived from the molecular shuffling of functional modules from nisin and 12 different class I and class II lantibiotic peptides (adapted from Schmitt et al. 2019). A blueprint of nisin with the Lan/MeLan Rings A–E and the hinge region is interpreted as five distinct modules B1–P3 according to the sequence B1/B2/P1/P2/P3 representing a lipid II binding domain, a flexible domain, and a pore-forming domain).
