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. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Eur J Med Chem. 2022 Oct 5;244:114807. doi: 10.1016/j.ejmech.2022.114807

Table 1.

Evaluation of effect of different zinc-binding groups on HDAC inhibitory activity by growth inhibition assay using HCT116 cells at a maximum concentration of 100 μM.

Compound HCT116 IC50 Compound HCT116 IC50

graphic file with name nihms-1890465-t0017.jpg >100 graphic file with name nihms-1890465-t0018.jpg >100
graphic file with name nihms-1890465-t0019.jpg >100 graphic file with name nihms-1890465-t0020.jpg >100
graphic file with name nihms-1890465-t0021.jpg >100 graphic file with name nihms-1890465-t0022.jpg >100
graphic file with name nihms-1890465-t0023.jpg >100 graphic file with name nihms-1890465-t0024.jpg >100
graphic file with name nihms-1890465-t0025.jpg >100 graphic file with name nihms-1890465-t0026.jpg >100
graphic file with name nihms-1890465-t0027.jpg >100 graphic file with name nihms-1890465-t0028.jpg >100
graphic file with name nihms-1890465-t0029.jpg >100 graphic file with name nihms-1890465-t0030.jpg >100
graphic file with name nihms-1890465-t0031.jpg >100 graphic file with name nihms-1890465-t0032.jpg 54.39 ± 6.02
graphic file with name nihms-1890465-t0033.jpg >100