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. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Eur J Med Chem. 2022 Oct 5;244:114807. doi: 10.1016/j.ejmech.2022.114807

Table 2.

Effect of linker length on growth inhibition of HCT116 cell line.

IC50 (μM) IC50 (μM) IC50 (μM) IC50 (μM) IC50 (μM)
Number of CH2 (n) 3 4 5 6 7
Compound number 14 10a 10b 10c 10d
graphic file with name nihms-1890465-t0034.jpg graphic file with name nihms-1890465-t0035.jpg graphic file with name nihms-1890465-t0036.jpg graphic file with name nihms-1890465-t0037.jpg graphic file with name nihms-1890465-t0038.jpg
HCT116 34.83 ± 5.65 20.26 ± 1.23 54.39 ± 6.02 9.14 ± 2.25 41.67 ± 5.60