Table 5.
NCI data of ten compounds against sixty cell lines displaying mean cell growth percentage (one-dose assay), GI50, TGI and LC50 values (five-dose assay). Positive growth percentages indicate cytostatic activity, while negative percentages imply cytotoxicity. The best results are highlighted in red. ND – Not Determined. GI50 values correspond to the drug concentration needed to prevent 50% cell growth. TGI (Total Growth Inhibition) values correspond to the concentrations needed to prevent complete cell growth. LC50 values are a measure of cytotoxicity, corresponding to the minimum concentrations needed to kill 50% of the target cells.
| Compound | 84 | 85 | 83 | 70 | 61 | 64 | 65 | 69 | 58 | 55 |
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Mean Growth % | −10.17 | −11.47 | −4.91 | 35 | −2.45 | 15.99 | 2.58 | 2.1 | −10.06 | 37.09 |
| GI50 (μM) | 1 | 0.93 | 1.23 | ND | 3.39 | 5.13 | 3.16 | 3.09 | 3.02 | ND |
| TGI (μM) | 8.51 | 11.4 | 12.3 | ND | 21.37 | 26.92 | 20.89 | 15.14 | 16.98 | ND |
| LC50 (μM) | 26.3 | 26.3 | 28.18 | ND | 28.84 | 35.48 | 31.62 | 29.51 | 22.91 | ND |