Table 3.
A multivariate and univariate Cox proportional hazards analysis of TMEM147 expression in HCC.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage (T2 & T3 & T4 vs. T1) | 370 | 2.126 (1.481–3.052) | <0.001 | 1.433 (0.798–2.574) | 0.228 |
| N stage (N0 vs. N1) | 258 | 2.029 (0.497–8.281) | 0.324 | ||
| M stage (M1 vs. M0) | 272 | 4.077 (1.281–12.973) | 0.017 | 1.208 (0.287–5.079) | 0.797 |
| Pathologic stage (Stage I & Stage II vs. Stage III & Stage IV) | 349 | 2.504 (1.727–3.631) | <0.001 | 1.944 (1.128–3.351) | 0.017 |
| Tumor status (tumor free vs. with tumor) | 354 | 2.317 (1.590–3.376) | <0.001 | 1.977 (1.239–3.155) | 0.004 |
| Gender (female vs. male) | 373 | 0.793 (0.557–1.130) | 0.2 | ||
| Race (White vs. Black or African American) | 361 | 0.791 (0.551–1.135) | 0.203 | ||
| Age (≤0 vs. >60) | 373 | 1.205 (0.850–1.708) | 0.295 | ||
| Weight (≤70 vs. >70) | 345 | 0.941 (0.657–1.346) | 0.738 | ||
| BMI (≤25 vs. >25) | 336 | 0.798 (0.550–1.158) | 0.235 | ||
| Histologic grade (G1 & G2 vs.G3 & G4) | 368 | 1.091 (0.761–1.564) | 0.636 | ||
| AFP (ng/ml) (≤400 vs. >400) | 279 | 1.075 (0.658–1.759) | 0.772 | ||
| Vascular invasion (no vs. yes) | 317 | 1.344 (0.887–2.035) | 0.163 | ||
| Fibrosis Ishak score (0 & 1/2 vs. 3/4 & 5/6) | 214 | 0.740 (0.445–1.232) | 0.247 | ||
| Adjacent hepatic tissue inflammation (none vs. mild & severe) | 236 | 1.194 (0.734–1.942) | 0.475 | ||
| TMEM147 (low vs. high) | 373 | 2.079 (1.458–2.966) | <0.001 | 2.121 (1.336–3.369) | 0.001 |
TMEM147: transmembrane protein 14.