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. 2023 Jun 10;6:626. doi: 10.1038/s42003-023-04974-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Heatmap shows the percentage of common SNP variants and indels between mice highlighting two major clusters defined by animal production center and mouse substrain used for genetic modification. C57BL/6NCrl (NCrl) mice were used by The Centre for Phenogenomics (TCP) and University of California, Davis (UCD); while C57BL/6NJ (NJ) mice were used by The Jackson Laboratory (JAX) and Baylor College of Medicine (BCM). Sample names are shown on the bottom and right side of figure using the production center abbreviation followed by target gene or substrain background and designation of treatment group either control (C) untreated mice or experimental (E) Cas9-edited founders. Both treatment groups were interspersed with each other consistent with no statistical difference observed between control and experimental mice.