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. Author manuscript; available in PMC: 2023 Jun 11.
Published in final edited form as: Neuroscientist. 2020 May 22;27(2):113–128. doi: 10.1177/1073858420914747

Figure 5.

Figure 5.

Pharmacological ablation of microglia with colony-stimulating factor 1 receptor antagonist PLX5622 allows for investigation of the role of microglia in the development of pain by stress. Mice were provided ad libitum diets of PLX5622 (PLX) or vehicle (Veh) chow for 14 days. (A, B) Following 14 days of treatment with PLX5622, microglia were eliminated from the spinal cord based on Iba-1 labeling for microglial activation. (C–E) The gene expression of microglia-related CX3CR1 was reduced by PLX5622 throughout the spinal cord in mice exposed to repeated social defeat (RSD; Stress) and those left undisturbed as controls. Modified from Sawicki and others (2019).