Table 2. Inflammatory soluble factors and their related signals promote malignant phenotypes of cancer stem cells.

Soluble factors and Inflammation related signal transduction pathways	Cancer stem cell type	Effects on cancer stem cell function	References
IL-6/HIF1	Breast cancer stem cell	Stemnness markers, sphere formation, self-renewal, metastases	Balamurugan et al. (2019)
SRSF1/circATP5B/miR-185-5p/HOXB5-IL-6/JAK2/STAT3	Glioma stem cells	Proliferation	Zhao et al. (2021)
TNF- α/NF- κB	Glioma stem cells	Cell viabilities, proliferation, invasion, neurospheres formation abilities, stemness markers	Jiang et al. (2022)
PGE2/NF- κB	Colorectal cancer stem cell	Expansion and Metastasis	Wang et al. (2015a)
CCL16/CCR2/GSK3 β/ β-catenin/OCT4	Breast cancer stem cell	Stemness markers	Shen et al. (2021)
IL-17/NF- κB/p38MAPK	Ovarian cancer stem cell	Self-renewal	Xiang et al. (2015)