Table 1.
List of top cis-eQTLs for 29 miRNAs associated with one of the 8 blood phenotypes correlated with ICU admission
| SNP | miRNA | SNP position | A1 | MAF | P Bonferroni | Distance SNP to miRNA (in BP) | Negative associations with ICU | Positive associations with ICU |
|---|---|---|---|---|---|---|---|---|
| rs34088055 | hsa-miR-5189-5p | Chr16:88469262 | T | 0.44 | 1.70E-16 | 296 | Neutrophil count | |
| rs7501512 | hsa-miR-6868-3p | Chr17:76097225 | A | 0.41 | 2.10E-12 | 794 | D-dimers | |
| rs1031034 | hsa-miR-1255a | Chr4:101302229 | A | 0.29 | 2.18E-10 | 28,136 | D-dimers | |
| rs2925983 | hsa-miR-7854-3p | Chr16:81533035 | C | 0.38 | 5.96E-07 | 907 | D-dimers | |
| rs12447180 | hsa-miR-5189-3p | Chr16:88451314 | C | 0.45 | 4.42E-06 | 17,670 | Neutrophil count, D-dimers | |
| rs28370965 | hsa-miR-4999-5p | Chr19:8408107 | T | 0.22 | 9.60E-06 | 18,747 | C-reactive protein | |
| rs9914549 | hsa-miR-4525 | Chr17:82667081 | G | 0.23 | 7.41E-05 | 1200 | Lymphocyte count | |
| rs1765566 | hsa-miR-3675-5p | Chr1:16708741 | T | 0.05 | 8.44E-05 | 150,247 | Interleukin-6 | |
| rs77318922 | hsa-miR-7976 | Chr3:127757054 | C | 0.07 | 8.64E-05 | 169,878 | C-reactive protein | |
| rs9364148 | hsa-miR-30a-3p | Chr6:71277249 | A | 0.07 | 0.000146 | 126,305 | Urea | D-dimers |
| rs1434282 | hsa-miR-181a-3p | Chr1:199041592 | C | 0.33 | 1.65E-04 | 182,502 | D-dimers | |
| rs11569501 | hsa-miR-3940-3p | Chr19:6691620 | A | 0.08 | 1.03E-03 | 275,165 | C-reactive protein | |
| rs76321536 | hsa-miR-636 | Chr17:76976432 | G | 0.12 | 0.001286 | 239,944 | D-dimers | |
| rs79260648 | hsa-miR-576-3p | Chr4:109205695 | C | 0.09 | 4.06E-03 | 283,057 | Urea | Neutrophil count, Neutrophil-to-lymphocyte ratio |
| rs1256522 | hsa-miR-625-3p | Chr14:65271311 | C | 0.44 | 0.004111 | 199,842 | Neutrophil count, Neutrophil-to-lymphocyte ratio | |
| rs1997243 | hsa-miR-339-3p | Chr7:1044141 | G | 0.14 | 0.00711 | 21,164 | C-reactive protein | |
| rs7710462 | hsa-miR-5003-3p | Chr5:172643217 | G | 0.07 | 0.007797 | 19,005 | C-reactive protein, Neutrophil-to-lymphocyte ratio | |
| rs60095937 | hsa-miR-3177-3p | Chr16:1732963 | A | 0.05 | 0.009533 | 2075 | D-dimers | |
| rs941449 | hsa-miR-6777-3p | Chr17:17746517 | C | 0.2 | 0.01199 | 66,963 | C-reactive protein, D-dimers, ICU admission | |
| rs4756822 | hsa-miR-6073 | Chr11:15695412 | T | 0.45 | 0.01375 | 274,143 | C-reactive protein, D-dimers | |
| rs2495972 | hsa-miR-1275 | Chr6:33964665 | G | 0.49 | 0.0181 | 35,353 | Lymphocyte count | |
| rs11768761 | hsa-miR-339-5p | Chr7:1030171 | G | 0.14 | 0.02617 | 7159 | Urea | |
| rs59088240 | hsa-miR-342-5p | Chr14:99827961 | A | 0.06 | 0.02867 | 281,712 | C-reactive protein, Neutrophil-to-lymphocyte ratio, D-dimers | |
| rs2382817 | hsa-miR-6810-3p | Chr2:218286495 | C | 0.49 | 0.03112 | 55,463 | Interleukin-6, D-dimers | |
| rs9787810 | hsa-miR-7155-5p | Chr11:64317826 | T | 0.24 | 0.0337 | 24,060 | Neutrophil count, D-dimers | |
| rs1499294 | hsa-miR-4742-3p | Chr1:224564806 | C | 0.32 | 0.04451 | 166,557 | D-dimers | |
| rs62130995 | hsa-miR-4746-5p | Chr19:4460286 | A | 0.13 | 0.0462 | 14,277 | D-dimers, ICU admission | |
| rs4144630 | hsa-miR-181a-2-3p | Chr9:124676921 | T | 0.36 | 0.04954 | 15,597 | Chloride, Lymphocyte count |
For each unique miRNA, the top SNP (lowest Bonferroni P value) is listed