Table 3. Interaction effect of FLT1 SNP rs3794396 major allele homozygotes (GG) in the major allele recessive model, and for heterozygotes (GC) in the heterozygote disadvantage model for each chronic condition affecting mortality risk (with the most statistically significant p value shown first).

Disease	GG vs. GC/CC		GC vs. GG/CC
	Beta †	p	Beta	p
Hypertension	–0.305	0.011	0.405	0.001
Diabetes	–0.175	0.135	0.137	0.253
Stroke	–0.466	0.156	0.401	0.242
CHD	–0.160	0.221	0.162	0.225

†Beta is coefficient of interaction term for FLT1 genotype with disease estimated from the full Cox model which included disease, FLT1 genotype and the interaction term of FLT1*disease, adjusted for age, and the covariates age, BMI, fasting glucose, smoking (pack-years), alcohol intake (ounces/month), physical activity index, type 2 diabetes, CHD, cancer, stroke and depression symptoms.