Table 4.
2-locus linkage disequilibria of non-Indigenous Chilean donors (sample CL-NI, n=92,788).
| Haplotype | f(ab) observed | f(a) | f(b) | D’ | f(ab) expected | p | α(HB) |
|---|---|---|---|---|---|---|---|
| B*39:09g-C*07:02g | 0.0945 | 0.0957 | 0.1848 | 0.9851 | 0.0177 | 0.00E+00 | 0.0022 |
| B*07:02g-C*07:02g | 0.0601 | 0.0623 | 0.1848 | 0.9554 | 0.0115 | 0.00E+00 | 0.0038 |
| B*08:01g-C*07:01g | 0.0464 | 0.0495 | 0.1032 | 0.9282 | 0.0051 | 0.00E+00 | 0.0071 |
| B*14:02g-C*08:02g | 0.0390 | 0.0418 | 0.0515 | 0.9290 | 0.0022 | 0.00E+00 | 0.0063 |
| B*35:01g-C*04:01g | 0.0374 | 0.0389 | 0.1379 | 0.9539 | 0.0054 | 0.00E+00 | 0.0042 |
| B*35:09-C*04:01g | 0.0300 | 0.0305 | 0.1379 | 0.9844 | 0.0042 | 0.00E+00 | 0.0023 |
| B*40:01g-C*03:04g | 0.0159 | 0.0169 | 0.0498 | 0.9354 | 0.0008 | 0.00E+00 | 0.0056 |
| B*13:02g-C*06:02g | 0.0140 | 0.0142 | 0.0721 | 0.9836 | 0.0010 | 1.41E-272 | 0.0100 |
| B*52:01g-C*12:02g | 0.0137 | 0.0170 | 0.0138 | 0.9948 | 0.0002 | 0.00E+00 | 0.0020 |
| B*14:01g-C*08:02g | 0.0114 | 0.0124 | 0.0515 | 0.9191 | 0.0006 | 2.05E-239 | 0.0125 |
| DRB1*04:07g-DQB1*03:02g | 0.0952 | 0.1791 | 0.0987 | 0.9564 | 0.0177 | 0.00E+00 | 0.0036 |
| DRB1*03:01g-DQB1*02:01g | 0.0864 | 0.1933 | 0.0867 | 0.9958 | 0.0168 | 0.00E+00 | 0.0019 |
| DRB1*15:01g-DQB1*06:02g | 0.0597 | 0.0651 | 0.0622 | 0.9578 | 0.0040 | 0.00E+00 | 0.0033 |
| DRB1*16:02g-DQB1*03:01g | 0.0454 | 0.2250 | 0.0467 | 0.9650 | 0.0105 | 0.00E+00 | 0.0028 |
| DRB1*01:01g-DQB1*05:01g | 0.0438 | 0.0948 | 0.0447 | 0.9777 | 0.0042 | 0.00E+00 | 0.0024 |
| DRB1*11:01g-DQB1*03:01g | 0.0428 | 0.2250 | 0.0439 | 0.9656 | 0.0099 | 0.00E+00 | 0.0026 |
| DRB1*14:02g-DQB1*03:01g | 0.0425 | 0.2250 | 0.0438 | 0.9631 | 0.0098 | 0.00E+00 | 0.0029 |
| DRB1*13:01g-DQB1*06:03g | 0.0368 | 0.0387 | 0.0388 | 0.9492 | 0.0015 | 0.00E+00 | 0.0050 |
| DRB1*11:04g-DQB1*03:01g | 0.0363 | 0.2250 | 0.0377 | 0.9516 | 0.0085 | 0.00E+00 | 0.0045 |
| DRB1*01:02g-DQB1*05:01g | 0.0290 | 0.0948 | 0.0300 | 0.9605 | 0.0028 | 0.00E+00 | 0.0031 |
| DRB1*14:01g-DQB1*05:03g | 0.0216 | 0.0223 | 0.0224 | 0.9697 | 0.0005 | 0.00E+00 | 0.0025 |
| DRB1*13:02g-DQB1*06:04g | 0.0209 | 0.0211 | 0.0307 | 0.9926 | 0.0006 | 0.00E+00 | 0.0021 |
| DRB1*04:02g-DQB1*03:02g | 0.0139 | 0.1791 | 0.0139 | 0.9981 | 0.0025 | 6.41E-180 | 0.0250 |
| DRB1*10:01g-DQB1*05:01g | 0.0121 | 0.0948 | 0.0121 | 0.9995 | 0.0011 | 3.09E-216 | 0.0167 |
| DRB1*13:03g-DQB1*03:01g | 0.0108 | 0.2250 | 0.0112 | 0.9532 | 0.0025 | 2.38E-114 | 0.0500 |
| DRB1*15:02g-DQB1*06:01g | 0.0104 | 0.0113 | 0.0105 | 0.9922 | 0.0001 | 1.37E-272 | 0.0083 |
Shown are all 26 significant allele pairs (p<0.05) with D’≥0.9 and f(ab)≥0.01. f(ab) = frequency of the partial haplotype; f(a) and f(b) = frequency of alleles a and b; D’=relative linkage disequilibrium; p = p-value reached by Fisher’s exact test; α(HB) = α-level after Holm-Bonferroni correction.