Table 5.
2-locus linkage disequilibria of Mapuche donors (sample CL-MP, n=1,933).
| Haplotype | f(ab) observed | f(a) | f(b) | D’ | f(ab) expected | p | α(HB) |
|---|---|---|---|---|---|---|---|
| B*39:09g-C*07:02g | 0.1577 | 0.1613 | 0.2447 | 0.9710 | 0.0395 | 2.012E-38 | 0.0019 |
| B*07:02g-C*07:02g | 0.0544 | 0.0554 | 0.2447 | 0.9760 | 0.0136 | 1.859E-13 | 0.0033 |
| B*35:09-C*04:01g | 0.0438 | 0.0446 | 0.1432 | 0.9795 | 0.0064 | 7.164E-16 | 0.0029 |
| B*08:01g-C*07:01g | 0.0403 | 0.0423 | 0.0922 | 0.9477 | 0.0039 | 1.928E-17 | 0.0023 |
| B*35:01g-C*04:01g | 0.0358 | 0.0386 | 0.1432 | 0.9165 | 0.0055 | 1.845E-12 | 0.0036 |
| B*14:02g-C*08:02g | 0.0336 | 0.0351 | 0.0476 | 0.9550 | 0.0017 | 5.395E-17 | 0.0025 |
| B*50:01g-C*06:02g | 0.0147 | 0.0162 | 0.0664 | 0.9006 | 0.0011 | 1.982E-07 | 0.0071 |
| B*13:02g-C*06:02g | 0.0118 | 0.0123 | 0.0664 | 0.9562 | 0.0008 | 1.350E-06 | 0.0100 |
| B*52:01g-C*12:02g | 0.0115 | 0.0158 | 0.0115 | 1.0000 | 0.0002 | 1.118E-07 | 0.0063 |
| B*40:01g-C*03:04g | 0.0103 | 0.0103 | 0.0475 | 1.0000 | 0.0005 | 9.091E-07 | 0.0083 |
| DRB1*04:07g-DQB1*03:02g | 0.1372 | 0.2126 | 0.1420 | 0.9574 | 0.0302 | 1.109E-36 | 0.0020 |
| DRB1*16:02g-DQB1*03:01g | 0.0708 | 0.2632 | 0.0730 | 0.9580 | 0.0192 | 3.727E-16 | 0.0028 |
| DRB1*03:01g-DQB1*02:01g | 0.0706 | 0.1681 | 0.0719 | 0.9790 | 0.0121 | 2.957E-22 | 0.0022 |
| DRB1*14:02g-DQB1*03:01g | 0.0654 | 0.2632 | 0.0669 | 0.9695 | 0.0176 | 5.443E-15 | 0.0031 |
| DRB1*15:01g-DQB1*06:02g | 0.0483 | 0.0513 | 0.0503 | 0.9580 | 0.0026 | 1.090E-23 | 0.0021 |
| DRB1*01:01g-DQB1*05:01g | 0.0370 | 0.0764 | 0.0373 | 0.9927 | 0.0028 | 3.905E-17 | 0.0024 |
| DRB1*11:01g-DQB1*03:01g | 0.0358 | 0.2632 | 0.0378 | 0.9279 | 0.0099 | 8.294E-09 | 0.0050 |
| DRB1*11:04g-DQB1*03:01g | 0.0356 | 0.2632 | 0.0368 | 0.9537 | 0.0097 | 1.326E-08 | 0.0056 |
| DRB1*13:01g-DQB1*06:03g | 0.0289 | 0.0304 | 0.0307 | 0.9490 | 0.0009 | 1.360E-16 | 0.0026 |
| DRB1*01:02g-DQB1*05:01g | 0.0228 | 0.0764 | 0.0235 | 0.9654 | 0.0018 | 4.942E-11 | 0.0038 |
| DRB1*04:04g-DQB1*03:02g | 0.0194 | 0.2126 | 0.0204 | 0.9374 | 0.0043 | 3.327E-06 | 0.0125 |
| DRB1*13:02g-DQB1*06:04g | 0.0148 | 0.0158 | 0.0238 | 0.9350 | 0.0004 | 1.681E-09 | 0.0045 |
| DRB1*14:01g-DQB1*05:03g | 0.0146 | 0.0156 | 0.0153 | 0.9500 | 0.0002 | 1.681E-09 | 0.0042 |
| DRB1*04:02g-DQB1*03:02g | 0.0127 | 0.2126 | 0.0129 | 0.9753 | 0.0027 | 1.267E-04 | 0.0167 |
Shown are all 24 significant allele pairs (p<0.05) with D’≥0.9 and f(ab)≥0.01. f(ab) = frequency of the partial haplotype; f(a) and f(b) = frequency of alleles a and b; D’=relative linkage disequilibrium; p = p-value reached by Fisher’s exact test; α(HB) = α-level after Holm-Bonferroni correction.