Table 1.

Significant and nominally significant Mendelian randomization estimates of the associations from Bacteroidetes on T1D.

Taxa	Gut microbiota (exposure)	Trait (outcome)	Nsnp	Methods	Beta	SE	OR (95%CI)	P value	P FDR	Heterogeneity		Horizontal pleiotropy
										Cochran’s Q	P value	Egger intercept	SE	P value
Phylum	Bacteroidetes	T1D	10	MR-Egger	-0.28	0.29	0.75 (0.43-1.32)	0.352	0.352	6.344	0.705	0.036	0.019	0.099
				Weighted median	0.21	0.15	1.24 (0.94-1.64)	0.146	0.146
				Inverse variance weighted	0.21	0.11	1.24 (1.01-1.53)	0.044	0.044
				Weighted mode	0.24	0.23	1.27 (0.82-1.97)	0.322	0.322
Class	Bacteroidia	T1D	13	MR-Egger	-0.11	0.26	0.90 (0.54-1.50)	0.682	0.864	6.528	0.887	0.025	0.017	0.176
				Weighted median	0.22	0.13	1.25 (0.97-1.60)	0.084	0.488
				Inverse variance weighted	0.24	0.09	1.28 (1.06-1.53)	0.009	0.085
				Weighted mode	0.22	0.19	1.24 (0.84-1.84)	0.276	0.926
Order	Bacteroidales	T1D	13	MR-Egger	-0.11	0.26	0.90 (0.54-1.50)	0.682	0.864	6.528	0.887	0.025	0.017	0.176
				Weighted median	0.22	0.12	1.25 (0.98-1.59)	0.067	0.488
				Inverse variance weighted	0.24	0.09	1.28 (1.06-1.53)	0.009	0.085
				Weighted mode	0.22	0.20	1.24 (0.85-1.82)	0.302	0.926
Family	Prevotellaceae	T1D	15	MR-Egger	-0.64	0.26	0.53 (0.31-0.88)	0.029	0.275	18.400	0.189	0.044	0.018	0.032
				Weighted median	-0.07	0.11	0.93 (0.76-1.15)	0.546	0.909
				Inverse variance weighted	-0.04	0.08	0.96 (0.82-1.14)	0.654	0.859
				Weighted mode	-0.01	0.18	0.99 (0.68-1.45)	0.968	0.985
Family	Rikenellaceae	T1D	16	MR-Egger	0.67	0.23	1.95 (1.23-3.08)	0.013	0.247	20.157	0.166	-0.045	0.017	0.016
				Weighted median	-0.02	0.11	0.98 (0.78-1.24)	0.884	0.909
				Inverse variance weighted	0.07	0.09	1.07 (0.90-1.27)	0.458	0.859
				Weighted mode	-0.10	0.24	0.91 (0.59-1.40)	0.682	0.926

Nsnp, number of snps.

Significant estimate is defined as P _FDR <0.1; nominal significant estimate is defined as P value <0.05.

Cochran’s Q-derived P value and MR-Egger intercept-derived P value < 0.05 is significant.