Skip to main content
. 2023 May 29;13:1163898. doi: 10.3389/fcimb.2023.1163898

Table 2.

Significant and nominally significant Mendelian randomization estimates of the associations from Firmicutes on T1D.

Taxa Gut microbiota (exposure) Trait (outcome) Nsnp Methods Beta SE OR(95%CI) P value P FDR Heterogeneity Horizontal pleiotropy
Cochran’s Q P value Egger intercept SE P value
Class Clostridia T1D 10 MR-Egger -0.38 0.41 0.68(0.30-1.54) 0.385 0.972 7.819 0.552 0.013 0.027 0.650
Weighted median -0.23 0.13 0.79(0.61-1.03) 0.081 0.856
Inverse variance weighted -0.19 0.10 0.83(0.68-1.00) 0.049 0.588
Weighted mode -0.22 0.20 0.80(0.54-1.18) 0.285 0.953
Family Family XI T1D 8 MR-Egger 0.35 0.30 1.42(0.79-2.55) 0.283 0.972 8.439 0.295 -0.066 0.039 0.147
Weighted median -0.19 0.07 0.82(0.71-0.95) 0.004 0.302
Inverse variance weighted -0.14 0.05 0.87(0.79-0.96) 0.007 0.378
Weighted mode -0.25 0.14 0.78(0.60-1.02) 0.111 0.953
Family Peptococcaceae T1D 8 MR-Egger -0.14 0.29 0.87(0.50-1.52) 0.634 0.988 9.908 0.194 -0.005 0.025 0.835
Weighted median -0.19 0.11 0.83(0.66-1.04) 0.102 0.856
Inverse variance weighted -0.20 0.09 0.82(0.68-0.98) 0.034 0.588
Weighted mode -0.22 0.17 0.80(0.58-1.11) 0.222 0.953
Family Veillonellaceae T1D 19 MR-Egger -0.01 0.12 0.99(0.78-1.26) 0.923 0.988 16.211 0.578 0.013 0.010 0.187
Weighted median 0.08 0.09 1.09(0.91-1.30) 0.360 0.858
Inverse variance weighted 0.13 0.06 1.14(1.02-1.29) 0.027 0.588
Weighted mode 0.00 0.13 1.00(0.79-1.28) 0.980 0.998
Genus Butyricicoccus T1D 8 MR-Egger 0.15 0.23 1.16(0.74-1.82) 0.552 0.988 9.059 0.248 0.008 0.020 0.705
Weighted median 0.12 0.14 1.12(0.86-1.47) 0.397 0.858
Inverse variance weighted 0.22 0.11 1.25(1.01-1.55) 0.041 0.588
Weighted mode 0.11 0.15 1.11(0.83-1.48) 0.492 0.953
Genus Dorea T1D 10 MR-Egger -0.38 0.30 0.69(0.38-1.24) 0.251 0.972 9.558 0.387 0.012 0.020 0.569
Weighted median -0.34 0.15 0.71(0.53-0.95) 0.020 0.540
Inverse variance weighted -0.21 0.10 0.81(0.66-1.00) 0.048 0.588
Weighted mode -0.44 0.25 0.64(0.39-1.05) 0.110 0.953
Genus Eubacterium eligens group T1D 6 MR-Egger -0.63 0.51 0.53(0.20-1.44) 0.282 0.972 5.572 0.350 0.015 0.040 0.728
Weighted median -0.44 0.16 0.64(0.47-0.88) 0.006 0.302
Inverse variance weighted -0.45 0.12 0.64(0.50-0.81) 0.000 0.031
Weighted mode -0.56 0.27 0.57(0.34-0.97) 0.093 0.953
Genus Holdemania T1D 14 MR-Egger 0.40 0.18 1.50(1.05-2.12) 0.044 0.972 16.392 0.229 -0.038 0.017 0.047
Weighted median -0.03 0.09 0.97(0.82-1.15) 0.763 0.896
Inverse variance weighted 0.03 0.07 1.03(0.90-1.18) 0.671 0.978
Weighted mode -0.18 0.19 0.84(0.56-1.26) 0.383 0.953
Genus Lachnospiraceae UCG008 T1D 11 MR-Egger -0.29 0.36 0.75(0.37-1.51) 0.437 0.972 13.119 0.217 0.014 0.037 0.708
Weighted median -0.12 0.08 0.89(0.76-1.05) 0.165 0.858
Inverse variance weighted -0.15 0.07 0.86(0.75-0.97) 0.019 0.588
Weighted mode -0.11 0.13 0.89(0.68-1.17) 0.410 0.953
Genus Ruminococcaceae UCG010 T1D 6 MR-Egger -0.27 0.28 0.76(0.44-1.31) 0.382 0.972 1.083 0.956 0.005 0.020 0.821
Weighted median -0.21 0.13 0.81(0.63-1.04) 0.097 0.856
Inverse variance weighted -0.21 0.10 0.81(0.66-0.99) 0.038 0.588
Weighted mode -0.22 0.16 0.80(0.58-1.11) 0.236 0.953
Genus Ruminococcus2 T1D 15 MR-Egger 0.22 0.25 1.24(0.76-2.04) 0.407 0.972 33.898 0.002 -0.016 0.020 0.432
Weighted median 0.19 0.11 1.22(0.98-1.51) 0.064 0.856
Inverse variance weighted 0.03 0.10 1.03(0.84-1.26) 0.769 0.986
Weighted mode 0.25 0.11 1.29(1.02-1.63) 0.038 0.953
Genus Veillonella T1D 5 MR-Egger -2.14 0.81 0.12(0.02-0.57) 0.077 0.972 9.763 0.045 0.180 0.062 0.063
Weighted median 0.38 0.15 1.46(1.08(1.98) 0.010 0.360
Inverse variance weighted 0.16 0.16 1.18(0.86-1.62) 0.313 0.835
Weighted mode 0.39 0.18 1.47(1.01-2.15) 0.100 0.953

Nsnp, the number of snps.

Significant estimate is defined as P FDR <0.1; nominal significant estimate is defined as P value <0.05.

Cochran’s Q-derived P value and MR-Egger intercept-derived P value < 0.05 is significant.