Table 1.
Study characteristics of included studies.
| Author | Year | Journal | Included patients | Hospital of inclusion | Type of endometrial cancer | FIGO | Grade | Mean Age | Mean BMI | Adipose tissue measurements | Unit | Imaging | Aim | Results |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nakamura | 2011 | Oncology reports | 122 | University Hospital, Okayama | All | All | I - 50% II - 20.5% III - 16.4% |
56.98 | X | VFA, SFA, TFA * | cm² | CT L4/L5 | Determine fat accumulation in visceral and subcutaneous adipose tissue on CT. Study the relationship of these findings with clinical variables in the various histological types. | Patients with type I endometrial cancer have a statistically significant association with obesity-related biological parameters. |
| Donkers | 2021 | European journal of Obstetrics & Gynecology and Reproductive Biology | 176 | Royal Cornwell Hospital Trust, UK (academical hospital) | All | All | III - 100% | 70.0 | 29.4 | SAV, VAV, TAV * | cm³ | CT L5/S1 | Investigate the relationship between body fat distribution, assessed by CT-scan, in relation to overall and disease-specific survival in high-grade (grade 3) endometrial cancer patients. | In non endometrioid endometrial cancer, high visceral fat percentage was an independent predictor of poor survival. Hypertension and diabetes mellitus were significantly associated with high BMI and high visceral fat percentage. |
| dePaula | 2020 | Nutrition | 545 | Leading cancer institute, Brazil | All | All | I - 16.1% II - 25.1% III - 58.8% |
64.5 | 29.8 | SATI, VATI, SMI * | cm²/m² | CT L3 | Provide the percentiles of distribution of body composition parameters according to cancer staging and body mass index (BMI). Identify the contribution of age, BMI, and cancer staging in the variation of the different parameters of body composition. | BMI was associated with body fat parameters and low-radiodensity SM index. Cancer stage was associated with SM index, mean SMD, and high-radiodensity SM index. |
| Ye | 2016 | BMC Cancer | 200 | Shanghai | All | I-III | I - 43.0% II - 42.5% III - 14.5% |
54 | 24.7 | VAT, SAT * | % | CT L4/L5 | To assess the effect of visceral adiposity on clinical and pathological characteristics in patients with endometrial cancer. | Viscerally obese patients were more likely to be old and have positive lymph nodes as well as extrauterine disease. |
| Tangen | 2019 | Gynecologic Oncology | 20 | Haukeland University Hospital, Bergen | Endometrioid/ non-endometrioid |
I/II | I/II - 50% III - 50% |
X | 25.2 | VAV, SAV * | cm³ | CT L5/S1 | Investigate the relation between level of steroids in blood and prognosis for endometrial cancer patients. | DHEA, DHEAS, progesterone, 21 OH progesterone and E1S were significantly increased in patients with long survival compared to patients with short survival. Estradiol levels were significantly positively correlated with visceral fat percentage. |
| Nattenmüller | 2018 | Oncotarget | 54 | University Hospital Heidelberg | X | All | X | X | 28.4 | TAT, VAT, SAT * | cm² | CT L3/L4 | Investigate the impact of body composition on overall survival (OS) in gynecological malignancies. | There was no statistically significant impact of any BC-parameters on OS. |
| Weelden | 2019 | BMC cancer | 39 | Radboudumc, Nijmegen (academical hostpital) |
All | All | I - 10% II - 41% III - 48% |
68.0 | 26.9 | SAV, VAV, TAV * | cm³ | CT L5/S1 | Explore the relation between BMI, visceral and subcutaneous fat volumes and sex steroids and lipids levels in endometrial cancer patients. | Serum estradiol is moderately correlated with BMI and VAV and strongly correlated with SAV. Other sex steroids and lipids have weak and moderate correlations with VAV or SAV |
| Celik | 2021 | Obstetrics and Gynaecology Research | 186 | Istanbul University Institute of Oncology | Endometrioid/ non-endometrioid |
All | I - 38.7% II/III - 61.3% |
62.9 | 32.9 | VAT, SAT * | cm² | MRI umbilical | Explore the relationship between VAT/SAT and survival in endometrial cancer patients. | Visceral adipose tissue is a significant and reliable prognostic indicator for endometrial cancer prognosis. |
| Mauland | 2017 | oncotarget | 227 | Haukeland University Hospital, Bergen | Endometrioid/ non-endometrioid |
All | I/II - 68% III - 32% |
66.9 | 27.9 | SAV, VAV, TAV * | ml, % | CT L5/S1 | Explore CT-quantified abdominal fat volumes and fat distribution in relation to BMI, clinicpathological features and survival in endometrial cancer patients. | High VAV% independently predicts reduced survival in EC patients. |
| Cho | 2020 | biomedical | 52 | Soonchunhyang University College of Medicine, Seoul | All | All | X | X | X | VFA, SFA, TFA * | cm² | CT L4/L5 | Predict the effect of subcutaneous and visceral fat on endometrial cancer. | Unlike subcutaneous fat, visceral fat is more directly related to the development of endometrial cancer. |
| Wada | 2022 | International journal of clinical oncology | 148 | National Hospital Organization Kyoto Medical Center, Kyoto? |
Endometrioid/ non-endometrioid |
All | X | 61.5 | 23.5 | Visceral fat, Subcutaneous fat, V/S ratio | cm² | CT umbilical | Investigate the association between prognostic factors of type 1 and 2 endometrial cancer and obesity parameters. | A V/S ratio > 0.5 is a possible factor for poor prognosis in type 1 endometrial cancer. |