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. 2023 May 29;14:1197265. doi: 10.3389/fimmu.2023.1197265

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Copyright © 2023 Yokoyama

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of the human BST-1/CD157 gene and locations of main single-nucleotide-polymorphisms (SNPs). Depicted is the exon-intron organization based on GenBank accession numbers NM_004334 and NC_000004. Black and open boxes represent protein-coding regions and untranslated regions, respectively. The locations of the SNPs on human chromosome 4 (chr4) are indicated in parentheses; numbers after colons represent genomic positions based on the human genome assembly the UCSC GRCh38/hg38 genome browser (http://www.genome.ucsc.edu/cgi-bin/hgGateway?db=hg38). SNPs in black, red and blue stand for those reported to be associated with Parkinson’s disease (PD; representative ones), autism spectrum disorder (ASD) and isolated REM sleep behavior disorder (iRBD), respectively. Single asterisk and double asterisks (in blue) represent association with major depressive disorder (MDD) and restless leg syndrome (RLS), respectively.