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. 2023 May 29;14:1199631. doi: 10.3389/fimmu.2023.1199631

Figure 1.

Figure 1

Immune checkpoints expressed on macrophages. We summarized the immune checkpoints expressed on macrophages including PD-1, PD-L1, PD-L2, SIRP-α, CD39, CD73, Siglec-10, VISTA, etc. PD-L1 and PD-L2 affect T cell functions; SIRP-α, CD39, CD73 and siglec-10 send “don’t eat me” signals to TAMs. PD-1: programmed cell death protein 1; PD-L1: programmed cell death-ligand 1; PD-L2: Programmed cell death-ligand 2; SIRP-α: signal regulatory protein α; VISTA: V-type immunoglobulin domain-containing suppressor of T cell activation; VSIG-3: V-set and Ig domain-containing 3; siglec-10: Sialic-acid-binding Ig-like lectin 10. The figure was created with BioRender.com.