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. 2023 May 29;14:1199631. doi: 10.3389/fimmu.2023.1199631

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Copyright © 2023 Xu, Wang, Yang, Wu, Li, Xiao, Xu, Xu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of action of CD47 and SIRP-α and optimal strategy. Left, CD47 binds to SIRP-α in macrophages and provide “don’t eat me” signals by different mechanisms; Right, screening for antibodies that do not bind erythrocytes, using SIRP-α inhibitors or antibodies, and developing bispecific antibodies make strategies to optimize target treatment. ITIM, immunoreceptor tyrosine-based inhibitory motif; ITAM, immunoreceptor tyrosine-based activation motifs; SHP-1/2, SH2-containing tyrosine phosphatase 1/2. The figure was created with BioRender.com.