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. 2023 May 29;14:1199631. doi: 10.3389/fimmu.2023.1199631

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Copyright © 2023 Xu, Wang, Yang, Wu, Li, Xiao, Xu, Xu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of CD39 and CD37. CD39 and CD73 hydrolyze extracellular ATP to adenosine, which impairs antibody-dependent cellular phagocytosis of macrophages and acts as a “don’t eat me” signal to mediate immunosuppression. A series of inhibitors targeting CD39 or CD73 have been summarized. ADCP, antibody-dependent cellular phagocytosis; ASO, antisense oligonucleotides. The figure was created with BioRender.com.