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. 2023 May 29;14:1126217. doi: 10.3389/fimmu.2023.1126217

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Copyright © 2023 Zhang, Zuo, Li, Geng, Ge, Song, Wang, Zhang, Wang, Zhao, Deng, Chai, Wang, Yang, Liu, Qiu, He, Yang, Ge, Wu, Zheng, Li, Chen, Sun and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein abundance assays and differential analysis of the biomarker panel and hemoglobin were performed in Validation cohort II. The biomarker panel included CAT, LTF, MMP9, RBP4, and SERPINA3. Validation cohort II (n = 310) included 141 CRC patients (red), 82 CRA patients (green), and 87 HCs (blue), with each dot representing one sample. The unpaired Wilcoxon rank test was used to analyze differences in protein abundance. ^* P< 0.05, ^** P< 0.01, ^*** P< 0.001, ^**** P< 0.0001, ns, not significant.