Table 7.
Interaction and bond distances of identified compounds from LSNHF with potassium channel (PDB: 4UUJ)-binding sites for anxiolytic activity.
| Protein | Ligand | Hydrogen-bond interactions |
Hydrophobic interactions |
||
|---|---|---|---|---|---|
| Amino acid residue | Distance (Å) | Amino acid residue | Distance (Å) | ||
| 4UUJ | Butanoic acid, 2-methyl- | ARG89 | 2.505 | LEU86 | 5.238 |
| PO411333 | 1.587 | LEU86 | 3.912 | ||
| Phenol, 2-methoxy-4-(2-propenyl)-, acetate | TRP87 | 2.192 | LEU86 | 4.467 | |
| THR85 | 2.302 | LEU86 | 5.352 | ||
| PO411333 | 2.344 | ||||
| PO411333 | 2.601 | ||||
| Undec-10-ynoic acid, tetradecyl ester | CYS90 | 2.819 | MET96 | 4.249 | |
| CYS90 | 3.934 | ||||
| VAL93 | 3.878 | ||||
| 7-Hexadecenal, (Z)- | ARG89 | 2.146 | |||
| LEU86 | 2.986 | ||||
| ARG89 | 2.847 | ||||
| 2-Tridecenoic acid, (E)- | PO411333 | 1.533 | ARG89 | 4.483 | |
| CYS90 | 4.702 | ||||
| VAL93 | 4.417 | ||||
| Oleic acid | ARG89 | 2.278 | TRP68 | 5.100 | |
| PO41133 | 1.843 | ||||
| PO41133 | 1.711 | ||||
| l-(+)-Ascorbic acid 2,6-dihexadecanoate | THR75 | 2.455 | |||
| Eicosanoic acid | ARG89 | 2.300 | TRP68 | 5.303 | |
| PO41133 | 1.442 | ||||
| Docosane, 1,22-dibromo- | THR75 | 2.775 | LEU86 | 4.949 | |
| ARG89 | 2.964 | ARG89 | 3.956 | ||
| Cholesterol margarate | ARG89 | 2.825 | ARG89 | 4.703 | |
| ARG89 | 4.877 | ||||
| VAL93 | 5.248 | ||||
| MET96 | 4.052 | ||||