Table 3.
Diagnostic Performance of RRM and Mayo Clinic Model Using Risk Thresholds
| Variable | Risk Threshold |
|||||||
|---|---|---|---|---|---|---|---|---|
| 10% |
85% |
|||||||
| All Patients (n = 489) |
Patients With Stage I or II Disease (n = 431) |
All Patients (n = 489) |
Patients With Stage I or II Disease (n = 431) |
|||||
| RRM | Mayo Clinic | RRM | Mayo Clinic | RRM | Mayo Clinic | RRM | Mayo Clinic | |
| True positive | 206 | 208 | 150 | 152 | 57 | 17 | 44 | 13 |
| False positive | 176 | 199 | 176 | 199 | 2 | 1 | 2 | 1 |
| True negative | 101 | 78 | 101 | 78 | 275 | 276 | 275 | 276 |
| False negative | 6 | 4 | 4 | 2 | 155 | 195 | 110 | 141 |
| Sensitivity (95% CI) | 97 (95-100) | 98 (96-100) | 97 (95-100) | 99 (97-100) | 27 (17-36) | 8 (0-19) | 29 (18-40) | 8 (0-21) |
| Specificity (95% CI) | 36 (29-44) | 28 (20-36) | 36 (29-44) | 28 (20-36) | 99 (97-100) | 100 (97-100) | 99 (97-100) | 100 (97-100) |
| PPV (95% CI)a | 54 (46-62) | 51 (42-60) | 46 (38-54) | 43 (34-52) | 97 (93-100) | 94 (86-100) | 96 (91-100) | 93 (82-100) |
| NPV (95% CI)a | 94 (91-98) | 95 (91-99) | 96 (93-99) | 98 (95-100) | 64 (54-74) | 59 (40-78) | 71 (60-82) | 66 (45-87) |
| PPV (95% CI)b | 35 (27-42) | 32 (24-41) | 34 (26-41) | 31 (23-40) | 93 (88-99) | 88 (76-100) | 93 (87-99) | 89 (75-100) |
| NPV (95% CI)b | 97 (95-100) | 97 (93-100) | 98 (95-100) | 98 (96-100) | 81 (76-90) | 78 (62-94) | 81 (75-90) | 77 (64-95) |
Data are presented as No. or value (95% CI), unless otherwise indicated. RRM = risk reclassification model.
a
Calculated at observed cancer prevalence of 43%.
b
Calculated at cancer prevalence of 25%.