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. 2023 Jun 12;3:81. doi: 10.1038/s43856-023-00307-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Top 3 Principal Components show separation of the sample by Acute Kidney Injury (AKI) (stage 2 or 3) case status. b External validation of AKI associated proteins in the discovery cohort shows high correlation with increased risk of AKI with significance of p < 0.05. (n = 62). The black line of regression runs diagonally across, and the gray shaded area represents the region wthin 95% Confidence Intervals around the regression line. c Expression heatmap shows a distinct separation of the cases and controls using the 62 significant proteins identified from the validation cohort in the discovery cohort. Source data for the PCA plots in a are found in the Synapse data repository syn35874390. Source Data for b are provided in Supplementary Data 1(sheet “Table 2”). Source Data for c is from the raw data matrix provided in syn35874390 but filtered for the 62 proteins documented in the sheet “Table 2” in Supplementary Data 1.