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. 2023 Jun 11;4(3):e306. doi: 10.1002/mco2.306

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© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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KAT2A coordinates histone acetylation with NRF2 transcription activity to promote Il1b and Nlrp3 expression. (A) Dual‐luciferase reporter analysis of the indicated promoter activation triggered by TRAF6 in HEK293T cells treated with the indicated amounts of MB‐3. (B) IGV analysis of NRF2 (GSE72946) and H3K9ac (GSE113226) signal in the gene locus of Il1b and Nlrp3. (C and D) ChIP analysis of NRF2 (C) and H3K9ac enrichment (D) at the indicated gene promoter in BMDMs pretreated with MB‐3 followed by stimulation with LPS (100 ng/mL) for 4 h. ^* p < 0.05; ^** p < 0.01; ^*** p < 0.001; ^**** p < 0.001. One‐way ANOVA (A, C, and D).